José C. Segovia

Unidades Centrales Científico-Técnicas — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

43h-index12.1kcitations222works3.62yr avg
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Research Topics

Virus-based gene therapy research(50), CRISPR and Genetic Engineering(50), Erythrocyte Function and Pathophysiology(30), Pluripotent Stem Cells Research(28), Hematopoietic Stem Cell Transplantation(19)

Publications208 total

SYNERGISTIC EFFECT OF IMMUNOTHERAPY AND RADIOTHERAPY IN A LOW-RADIATION RESPONSIVE ANIMAL MODEL: CHALLENGES OF MICE STUDIES IN PROTON THERAPY FACILITIES
International Journal of Particle Therapy·2025Open Access
Metabolic Rigidity as a Mechanical Barrier to Malaria: Flickering Loss in <scp>PKLR</scp> ‐Deficient Erythrocytes
The FASEB Journal·2025
A presumed mouse parvovirus with overlooked high toxicity for human primitive CD34 <sup>+</sup> hematopoietic precursors <i>in vitro</i> and in bone marrow-humanized mice
Microbiology Spectrum·2025Open Access
Harnessing DNA barcoding to enhance and sustain polyclonality in gene-edited hematopoietic stem cells
Molecular Therapy — Methods & Clinical Development·2025Open Access
GPR41 and GPR43 modulate rodent pancreatic α-cell function and growth
Life Sciences·2025Open Access
Metabolic Rigidity as a Mechanical Barrier to Malaria: Flickering Loss in PKLR-Deficient Erythrocytes
2025Open Access
HSC engraftment is enhanced by combining mobilization with anti-C-Kit and Anti-CD47-based conditioning in hematopoietic transplant
Molecular Therapy·2025· 3 citedOpen Access
Coagulation factor V deficiency. From mutation to “cure” by advanced therapies
Anales de la Real Academia Nacional de Farmacia·2025Open Access
Haematopoietic gene therapy of non-conditioned patients with Fanconi anaemia-A: results from open-label phase 1/2 (FANCOLEN-1) and long-term clinical trials
The Lancet·2024· 20 cited
RP-L301, a Lentiviral-Mediated Gene Therapy for Pyruvate Kinase Deficiency (PKD): A Phase 2 Clinical Trial Design
Blood·2024Open Access
Effect of virgin olive oil as spreadable preparation on atherosclerosis compared to dairy butter in Apoe-deficient mice
Journal of Physiology and Biochemistry·2024· 5 citedOpen Access
Lentivirus-mediated gene therapy corrects ribosomal biogenesis and shows promise for Diamond Blackfan anemia
JCI Insight·2024· 9 citedOpen Access
Restored glyoxylate metabolism after AGXT gene correction and direct reprogramming of primary hyperoxaluria type 1 fibroblasts
iScience·2024· 10 citedOpen Access
A human genome editing–based <i>MLL</i>::<i>AF4</i> ALL model recapitulates key cellular and molecular leukemogenic features
Blood·2023· 6 cited
Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
Cellular and Molecular Life Sciences·2023· 29 citedOpen Access
Comprehensive characterization of a novel, oncogenic and targetable <scp>SEPTIN6</scp>::<scp>ABL2</scp> fusion in <scp>T‐ALL</scp>
British Journal of Haematology·2023· 5 citedOpen Access
Specific correction of pyruvate kinase deficiency-causing point mutations by CRISPR/Cas9 and single-stranded oligodeoxynucleotides
Frontiers in Genome Editing·2023· 2 citedOpen Access
Figure S2 from IKKβ-Mediated Resistance to Skin Cancer Development Is &lt;i&gt;Ink4a/Arf-&lt;/i&gt;Dependent
2023Open Access
Figure S1 from IKKβ-Mediated Resistance to Skin Cancer Development Is &lt;i&gt;Ink4a/Arf-&lt;/i&gt;Dependent
2023Open Access
Figure S4 from IKKβ-Mediated Resistance to Skin Cancer Development Is &lt;i&gt;Ink4a/Arf-&lt;/i&gt;Dependent
2023Open Access
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Frequent Co-authors

Juan A. Bueren(26), Óscar Quintana-Bustamante(12), Guillermo Güenechea(9), Susana Navarro(8), Paula Rı́o(7), María L. Lamana(7), Rosa María Pérez Yáñez(7), Rebeca Sánchez‐Domínguez(6), José Antonio Casado(6), Julián Sevilla(6), Israel Orman(6), Miriam Hernando-Rodríguez(5), Jordi Surrallés(5), Manuel Ramı́rez(4), María Fernández-García(4), Ariana Jacome(4), María Á. Navarro(4), José M. Arbones-Mainar(4), Joaquín C. Surra(4), Jesús Osada(4)