Pandian Nagakannan

St. Jude Children's Research Hospital — United States

Medicine · Health Sciences

22h-index2.1kcitations33works51.72yr avg
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Research Topics

Autophagy in Disease and Therapy(6), Inflammasome and immune disorders(5), Mitochondrial Function and Pathology(4), interferon and immune responses(4), Redox biology and oxidative stress(4)

Publications33 total

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Cell·2025· 10 citedOpen Access
TXNIP promotes ferroptosis through NCOA4 mediated ferritinophagy
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2025· 2 cited
NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation
Cell·2024· 143 citedOpen Access
NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs
Cell·2023· 317 citedOpen Access
PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality
The Journal of Immunology·2022· 218 citedOpen Access
Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method
Cellular and Molecular Life Sciences·2022· 77 citedOpen Access
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Science Immunology·2022· 290 citedOpen Access
Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease
Aging Cell·2021· 41 citedOpen Access
Cathepsin B is an executioner of ferroptosis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2020· 87 cited
Role of lysosomes in oxidative stress induced regulated cell death
Mspace (University of Manitoba)·2020Open Access
Oxidative damage of lysosomes in regulated cell death systems: Pathophysiology and pharmacologic interventions
Free Radical Biology and Medicine·2020· 33 cited
Acute upregulation of bone morphogenetic protein-4 regulates endogenous cell response and promotes cell death in spinal cord injury
Experimental Neurology·2019· 20 cited
Upregulation of Thioredoxin-Interacting Protein in Brain of Amyloid-β Protein Precursor/Presenilin 1 Transgenic Mice and Amyloid-β Treated Neuronal Cells
Journal of Alzheimer s Disease·2019· 34 cited
Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease
Free Radical Biology and Medicine·2019· 30 cited
Inhibition of VDAC1 Protects Against Glutamate-Induced Oxytosis and Mitochondrial Fragmentation in Hippocampal HT22 Cells
Cellular and Molecular Neurobiology·2018· 58 citedOpen Access
Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: implications for Alzheimer’s disease
Free Radical Biology and Medicine·2018
Glucocorticoid Upregulates Thioredoxin-interacting Protein in Cultured Neuronal Cells
Neuroscience·2018· 15 cited
Contribution of Thioredoxin1 in Modulation of Lysosomal Autophagy
Free Radical Biology and Medicine·2017· 3 cited
Lysosomal Permeabilization Facilitate Mitochondria-mediated Cell Death in Ferroptosis and Oxytosis
Free Radical Biology and Medicine·2017· 2 cited
Differential redox sensitivity of cathepsin B and L holds the key to autophagy-apoptosis interplay after Thioredoxin reductase inhibition in nutritionally stressed SH-SY5Y cells
Free Radical Biology and Medicine·2017· 39 cited
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Frequent Co-authors

Eftekhar Eftekharpour(17), Veeresh Prabhakar Veerapur(9), B.S. Thippeswamy(8), B. D. Shivasharan(7), Thirumala‐Devi Kanneganti(6), M. Rabiul Islam(6), Yaqiu Wang(4), Peter Vogel(4), Balamurugan Sundaram(3), Raghvendra Mall(3), R. K. Subbarao Malireddi(3), Rajendra Karki(3), Soheila Karimi‐Abdolrezaee(3), Benedict C. Albensi(3), Junfeng Wang(3), Roman Sarkar(2), SangJoon Lee(2), Bhesh Raj Sharma(2), Shondra M. Pruett‐Miller(2), Rebecca E. Tweedell(2)