Sean Oldham

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index5.7kcitations30works0.02yr avg
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Research Topics

Genetics, Aging, and Longevity in Model Organisms(11), Protein Kinase Regulation and GTPase Signaling(7), PI3K/AKT/mTOR signaling in cancer(7), Neurobiology and Insect Physiology Research(5), TGF-β signaling in diseases(5)

Publications29 total

Modeling spatial, developmental, physiological, and topological constraints on human brain connectivity
2021· 9 citedOpen Access
A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells
UNC Libraries·2021Open Access
PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase
Cell Reports·2015· 99 citedOpen Access
Drosophila: A Model for Understanding Obesity and Diabetic Complications
Experimental and Clinical Endocrinology & Diabetes·2012· 34 cited
Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms
Trends in Endocrinology and Metabolism·2011· 75 citedOpen Access
Bunched, the homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth-4
Figshare·2011Open Access
High-Fat-Diet-Induced Obesity and Heart Dysfunction Are Regulated by the TOR Pathway in Drosophila
Cell Metabolism·2010· 387 citedOpen Access
The Neurobiology of Aging
Elsevier eBooks·2010
<i>d4eBP</i> acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in <i>Drosophila</i>
Aging Cell·2009· 91 citedOpen Access
Regulation of obesity, heart function, and lifespan by the nutrient sensing TOR pathway
The FASEB Journal·2009
Role of Obesity and Aging on Intestinal Stem Cell Function
The FASEB Journal·2009
Bunched, the Drosophilahomolog of the mammalian tumor suppressor TSC-22, promotes cellular growth
BMC Developmental Biology·2008· 25 citedOpen Access
Antioxidants protect <i>PINK1</i> -dependent dopaminergic neurons in <i>Drosophila</i>
Proceedings of the National Academy of Sciences·2006· 198 citedOpen Access
Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity
Cell Metabolism·2006· 173 citedOpen Access
TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model
Current Biology·2006· 264 citedOpen Access
The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-α/Sima
Journal of Cell Science·2005· 109 cited
Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
Trends in Cell Biology·2003· 552 cited
The<i>Drosophila</i>insulin/IGF receptor controls growth and size by modulating PtdIns<i>P</i>3 levels
Development·2002· 172 cited
Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB
Science·2002· 204 cited
Extension of Life-Span by Loss of CHICO, a <i>Drosophila</i> Insulin Receptor Substrate Protein
Science·2001· 1.4k cited
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Frequent Co-authors

Ernst Hafen(9), Hugo Stocker(7), Rolf Bodmer(6), Channing J. Der(6), Suzanne Graham(5), Robert J. Coffey(5), Ryan T. Birse(4), Nywana Sizemore(4), Soda Diop(3), Karen Ocorr(3), Lisa M. Gangarosa(3), Ruth Böhni(2), Walter Brogiolo(2), Joan Choi(2), Muriel Laffargue(2), Matthias P. Wymann(2), Claire Davies(2), Robert Wessells(2), Ramona Graves‐Deal(2), Adrienne D. Cox(2)