Denis Wirtz

Johns Hopkins University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

94h-index32.1kcitations540works3.42yr avg
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Research Topics

Cellular Mechanics and Interactions(176), Cancer Cells and Metastasis(51), Cancer, Hypoxia, and Metabolism(50), Cell Adhesion Molecules Research(46), 3D Printing in Biomedical Research(44)

Publications540 total

Methods to analyze cell migration data: fundamentals and practical guidelines
Nature Methods·2025· 1 citedOpen Access
Selecting the optimal cell migration assay: fundamentals and practical guidelines
Nature Methods·2025· 1 citedOpen Access
Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics
2025· 1 citedOpen Access
Author response: Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis
2025Open Access
Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis
2025Open Access
Mechano-induced patterned domain formation by monocytes
Nature Materials·2025
Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells
2025· 2 citedOpen Access
Optimization of velocity receptor transduction in CAR T cells
2025Open Access
NLTD 2.0: A Nonlinear Framework for Robust and Customizable Color Deconvolution in Histopathology
2025Open Access
Abstract A046: Quantitative, multiplex assessment of the pancreatic microenvironment in individuals at high-risk of pancreatic cancer reveals differences in tumorigenesis
Cancer Research·2025
3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors
2025· 2 citedOpen Access
3D map-guided modeling of functional endometrial tissue using multi-compartment assembloids
2025Open Access
Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during senescence induction
Aging·2025· 1 citedOpen Access
Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories
Cell·2025· 23 citedOpen Access
Spatial proteomics and transcriptomics reveal early immune cell organization in pancreatic intraepithelial neoplasia
JCI Insight·2025· 3 citedOpen Access
PIVOT: an open-source tool for multi-omic spatial data registration
2025· 3 citedOpen Access
Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues
Cell Reports Methods·2025· 7 citedOpen Access
InterpolAI: deep learning-based optical flow interpolation and restoration of biomedical images for improved 3D tissue mapping
Nature Methods·2025· 8 citedOpen Access
CODAvision: best practices and a user-friendly interface for rapid, customizable segmentation of medical images
2025· 4 citedOpen Access
Integration of nuclear morphology and 3D imaging to profile cellular neighborhoods
2025· 4 citedOpen Access
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Frequent Co-authors

Yiider Tseng(9), Daniele M. Gilkes(8), Gregg L. Semenza(6), Pei-Hsun Wu(6), Shyam B. Khatau(5), Didier Hodzic(5), Sean X. Sun(5), Pallavi Chaturvedi(5), Κωνσταντίνος Κωνσταντόπουλος(4), Jerry Lee(4), Christopher M. Hale(4), Gregory D. Longmore(4), Thomas P. Kole(4), Justin Hanes(3), Scot C. Kuo(3), Phillip J. Stewart-Hutchinson(3), Colin L. Stewart(3), Stephanie I. Fraley(3), Yunfeng Feng(3), Saumendra Bajpai(3)