Carrie L. Lomelino

University of Florida — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index1.6kcitations54works2.52yr avg
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Research Topics

Enzyme function and inhibition(43), Synthesis and Catalytic Reactions(31), Chemical Reactions and Mechanisms(20), Cholinesterase and Neurodegenerative Diseases(9), Phenothiazines and Benzothiazines Synthesis and Activities(6)

Publications54 total

Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore
European Journal of Medicinal Chemistry·2025· 1 cited
Human carbonic anhydrase II in complex with TDP4
2025
Fast product release requires active-site water dynamics in carbonic anhydrase
Nature Communications·2025· 5 citedOpen Access
Design, Anticancer Activity, and Mechanistic Evaluation of a Novel Class of Selective Human Carbonic Anhydrase IX Inhibitors Featuring a Trifluorodihydroxypropanone Pharmacophore
SSRN Electronic Journal·2025Open Access
Disruption of the Physical Interaction Between Carbonic Anhydrase IX and the Monocarboxylate Transporter 4 Impacts Lactate Transport in Breast Cancer Cells
International Journal of Molecular Sciences·2024· 6 citedOpen Access
XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures
Acta Crystallographica Section D Structural Biology·2024· 3 citedOpen Access
The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII
Journal of Enzyme Inhibition and Medicinal Chemistry·2022· 34 citedOpen Access
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes
Journal of Medicinal Chemistry·2021· 19 citedOpen Access
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action
Journal of Medicinal Chemistry·2020· 106 citedOpen Access
Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(furan-2-ylmethyl)-N-(4-sulfamoylphenethyl)acetamide
2020
Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(4-fluorobenzyl)-N-(4-sulfamoylphenethyl)acetamide
2020
Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid
2020
Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells
European Journal of Medicinal Chemistry·2020· 70 citedOpen Access
The splicing component ISY1 regulates APE1 in base excision repair
DNA repair·2019· 15 citedOpen Access
“A Sweet Combination”: Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII
Journal of Medicinal Chemistry·2019· 38 cited
Human Carbonic Anhydrase 2 complexed with SB4-208
2019
Carbonic anhydrase 9 in complex with SB4197
2019· 14 citedOpen Access
Carbonic anhydrase 2 in complex with SB4197
2019
Abstract 1758: Splicing component ISY1 interacts with APE1 and regulates base excision repair
Molecular and Cellular Biology / Genetics·2019· 1 cited
Abstract 1758: Splicing component ISY1 interacts with APE1 and regulates base excision repair
Cancer Research·2019
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Frequent Co-authors

Robert McKenna(42), Claudiu T. Supuran(16), Brian P. Mahon(14), Jacob T. Andring(13), Akilah B. Murray(9), Alessio Nocentini(8), Jacob Combs(8), Silvia Bua(6), Paola Gratteri(6), Fabrizio Carta(5), Jin Kyun Kim(5), Chae Un Kim(5), Gianluca Bartolucci(4), Lorenzo Di Cesare Mannelli(4), Carla Ghelardini(4), Jenna M. Driscoll(4), Nicolino Pala(4), Daniela Vullo(4), Mario Sechi(4), R. McKenna(4)