Brian P. Mahon

Bristol-Myers Squibb (Germany) — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index1.4kcitations73works0.32yr avg
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Research Topics

Enzyme function and inhibition(40), Synthesis and Catalytic Reactions(25), Chemical Reactions and Mechanisms(19), Microtubule and mitosis dynamics(9), Enzyme Structure and Function(9)

Publications73 total

Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway
Journal of Medicinal Chemistry·2025
Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore
European Journal of Medicinal Chemistry·2025· 1 cited
Human carbonic anhydrase II in complex with TDP4
2025
Design, Anticancer Activity, and Mechanistic Evaluation of a Novel Class of Selective Human Carbonic Anhydrase IX Inhibitors Featuring a Trifluorodihydroxypropanone Pharmacophore
SSRN Electronic Journal·2025Open Access
Conformational states of the microtubule nucleator, the γ-tubulin ring complex
2023· 3 citedOpen Access
Integrated model of the vertebrate augmin complex
Nature Communications·2023· 16 citedOpen Access
The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)
eLife·2022· 21 citedOpen Access
Author response: The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)
2022Open Access
Integrated Model of the Vertebrate Augmin Complex
2022· 2 citedOpen Access
How Microtubules Build the Spindle Branch by Branch
Annual Review of Cell and Developmental Biology·2022· 18 citedOpen Access
The conserved centrosomal motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)
2022· 2 citedOpen Access
Untitled
Annual Review of Cell and Developmental Biology·2022· 1 citedOpen Access
Cdk5rap2 dimers activate microtubule nucleation by opposing inhibitory pathways
Biophysical Journal·2022
Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX
International Journal of Molecular Sciences·2020· 7 citedOpen Access
Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX
Acta Crystallographica Section D Structural Biology·2019· 15 citedOpen Access
Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative
Journal of Structural Biology·2019· 15 citedOpen Access
Joint X-ray and neutron protein crystallography for the study of enzyme-isoform selectivity by small-molecule inhibitors
Acta Crystallographica Section A Foundations and Advances·2018
Carbonic anhydrase II microcrystals suitable for XFEL studies
Acta Crystallographica Section F Structural Biology Communications·2018· 8 citedOpen Access
Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex)
2018· 9 cited
Carbonic Anhydrases: Role in pH Control and Cancer
Metabolites·2018· 269 citedOpen Access
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Frequent Co-authors

Robert McKenna(35), Carrie L. Lomelino(11), Claudiu T. Supuran(9), Melissa A. Pinard(8), Sophie M. Travis(7), Daniela Vullo(6), Sabine Petry(6), Michael J Rale(5), Katarina Koruza(5), Jenna M. Driscoll(4), Avni Bhatt(4), Wolfgang Knecht(4), S. Zoë Fisher(4), Mam Y. Mboge(3), Susan C. Frost(3), Sally‐Ann Poulsen(3), Fabrizio Carta(3), Cynthia Okoh(3), Chingkuang Tu(3), Mavis Agbandje‐McKenna(3)