Melissa A. Pinard

National Institutes of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.1kcitations42works0.02yr avg
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Research Topics

Enzyme function and inhibition(29), Cholinesterase and Neurodegenerative Diseases(11), Chemical Reactions and Mechanisms(8), Crystallization and Solubility Studies(6), Phenothiazines and Benzothiazines Synthesis and Activities(6)

Publications42 total

Cover Feature: Structural Mapping of Anion Inhibitors to β‐Carbonic Anhydrase psCA3 from <i>Pseudomonas aeruginosa</i> (ChemMedChem 19/2018)
ChemMedChem·2018Open Access
Structural Mapping of Anion Inhibitors to β‐Carbonic Anhydrase psCA3 from <i>Pseudomonas aeruginosa</i>
ChemMedChem·2018· 31 cited
Beta Carbonic anhydrase in complex with thiocyanate
2018
Beta Carbonic anhydrase in complex with a sulfonamide anion
2018
Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function
Biochemistry·2017· 22 cited
Parvovirus Capsid Structures Required for Infection: Mutations Controlling Receptor Recognition and Protease Cleavages
Journal of Virology·2016· 43 citedOpen Access
Cryoannealing-induced space-group transition of crystals of the carbonic anhydrase psCA3
Acta Crystallographica Section F Structural Biology Communications·2016· 9 citedOpen Access
Crystal Structure of the Beta Carbonic Anhydrase psCA3 isolated from Pseudomonas aeruginosa - alternate crystal packing form
2016
Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities
Journal of Biological Chemistry·2015· 49 citedOpen Access
Carbon Dioxide “Trapped” in a β-Carbonic Anhydrase
Biochemistry·2015· 35 citedOpen Access
A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX
Acta Crystallographica Section F Structural Biology Communications·2015· 26 citedOpen Access
Observed surface lysine acetylation of human carbonic anhydrase II expressed in <i>Escherichia coli</i>
Protein Science·2015· 8 citedOpen Access
Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium<i>Thiomicrospira crunogena</i>XCL-2: insights into engineering thermostable enzymes for CO<sub>2</sub>sequestration
Acta Crystallographica Section D Biological Crystallography·2015· 20 citedOpen Access
Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure–Activity Relationships of Glucosyl-Based Sulfamates
Journal of Medicinal Chemistry·2015· 27 citedOpen Access
Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa
Bioorganic & Medicinal Chemistry·2015· 65 citedOpen Access
Capturing Carbon Dioxide in beta Carbonic Anhydrase
2015
Activity and anion inhibition studies of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium
Bioorganic & Medicinal Chemistry Letters·2015· 9 citedOpen Access
Genetically engineered Carbonic anhydrase IX
2015
Sucrose Binding Site in genetically engineered Carbonic anhydrase IX
2015
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects
Bioorganic & Medicinal Chemistry·2015· 144 citedOpen Access
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Frequent Co-authors

Robert McKenna(29), Mayank Aggarwal(11), Brian P. Mahon(9), Claudiu T. Supuran(8), Kadir Aslan(8), Christopher D. Boone(4), Daniela Vullo(4), Marianna A. Patrauchan(4), Mavis Agbandje‐McKenna(4), Akilah B. Murray(4), Fabrizio Carta(3), Andrea Scozzafava(3), Carrie L. Lomelino(3), Chingkuang Tu(3), Natalia A. Díaz-Torres(3), David Silverman(2), Shalaka Lotlikar(2), Sriram Ambadapadi(2), Scott A. Tibbetts(2), Murat Bozdağ(2)