Layla Ghaffari

Thomas Jefferson University — United States

Medicine · Health Sciences

7h-index507citations15works0.02yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(6), Genetic Neurodegenerative Diseases(5), MicroRNA in disease regulation(3), Cancer-related molecular mechanisms research(3), Neurogenetic and Muscular Disorders Research(3)

Publications15 total

Neuronal activity-dependent gene dysregulation in <i>C9orf72</i> i <sup>3</sup> Neuronal models of ALS/FTD pathogenesis
American Journal of Physiology-Cell Physiology·2025Open Access
Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS
Journal of Clinical Investigation·2025Open Access
Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS
2025Open Access
Neuronal Activity-Dependent Gene Dysregulation in <i>C9orf72</i> i <sup>3</sup> Neuronal Models of ALS/FTD Pathogenesis
2025Open Access
Differential response of C9orf72 transcripts following neuronal depolarization
iScience·2023· 2 citedOpen Access
Divergent Transcriptional Response of the C9orf72 Gene Locus Following Neuronal Depolarization in C9-NRE iPSC-Cortical Neurons
SSRN Electronic Journal·2023Open Access
Breakdown of the central synapses in C9orf72-linked ALS/FTD
Frontiers in Molecular Neuroscience·2022· 16 citedOpen Access
The effects of molecular crowding and CpG hypermethylation on DNA G-quadruplexes formed by the C9orf72 nucleotide repeat expansion
Scientific Reports·2021· 7 citedOpen Access
C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
Neuron·2021· 143 citedOpen Access
Representing Diversity in the Dish: Using Patient-Derived in Vitro Models to Recreate the Heterogeneity of Neurological Disease
Frontiers in Neuroscience·2018· 33 citedOpen Access
Abstract 1314: Evaluating payload delivery to the CNS from surface-modified nanoparticles
Cancer Research·2016
micro <scp>RNA</scp> changes in liver tissue associated with fibrosis progression in patients with hepatitis C
Liver International·2015· 37 citedOpen Access
Label-free microscopic assessment of glioblastoma biopsy specimens prior to biobanking
Neurosurgical FOCUS·2014· 22 citedOpen Access
Identification of extracellular miRNA in human cerebrospinal fluid by next-generation sequencing
RNA·2013· 187 citedOpen Access
Comparison of Analysis Tools for miRNA High Throughput Sequencing Using Nerve Crush as a Model
Frontiers in Genetics·2013· 60 citedOpen Access

Frequent Co-authors

Aaron R. Haeusler(6), Davide Trotti(5), Kendall Van Keuren‐Jensen(4), Raghu Metpally(3), Elizabeth Carlson(3), Amanda Courtright(2), Waibhav Tembe(2), Rita Sattler(2), Ivana Malenica(2), Alexander Starr(2), Emily Welebob(2), Ashley Boehringer(2), Kelly Cyliax(2), Piera Pasinelli(2), Michael E. Bekier(2), Emile Pinarbasi(2), Jack J. Mesojedec(2), Martina de Majo(2), Erik M. Ullian(2), Mark Koontz(2)