Aaron R. Haeusler

Thomas Jefferson University — United States

Medicine · Health Sciences

15h-index3.5kcitations37works2.12yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(25), Neurogenetic and Muscular Disorders Research(18), Genetic Neurodegenerative Diseases(11), DNA and Nucleic Acid Chemistry(8), Parkinson's Disease Mechanisms and Treatments(4)

Publications37 total

Intrathecal (G <sub>4</sub> C <sub>2</sub> ) <sub>149</sub> delivery in C9orf72-deficient mice yields mild motor dysfunction and ALS/FTD pathological hallmarks
2026Open Access
A CAR-T Cell-Based Strategy for Eliminating Pathogenic Microglia in ALS
2025Open Access
RNA G-Quadruplexes Function as a Tunable Switch of FUS Phase Separation
2025· 1 citedOpen Access
Neuronal activity-dependent gene dysregulation in <i>C9orf72</i> i <sup>3</sup> Neuronal models of ALS/FTD pathogenesis
American Journal of Physiology-Cell Physiology·2025Open Access
Increased neuronal activity restores circadian function in <i>Drosophila</i> models of C9orf72-ALS/FTD
2025Open Access
Neuronal Activity-Dependent Gene Dysregulation in <i>C9orf72</i> i <sup>3</sup> Neuronal Models of ALS/FTD Pathogenesis
2025Open Access
Increased Neuronal Activity Restores Circadian Function in Drosophila Models of C9orf72-ALS/FTD
SSRN Electronic Journal·2025Open Access
Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes
EMBO Reports·2024· 12 citedOpen Access
The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD
Communications Biology·2024· 6 citedOpen Access
Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit
Neurology and Therapy·2023· 31 citedOpen Access
Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes
2023Open Access
Differential response of C9orf72 transcripts following neuronal depolarization
iScience·2023· 2 citedOpen Access
Divergent Transcriptional Response of the C9orf72 Gene Locus Following Neuronal Depolarization in C9-NRE iPSC-Cortical Neurons
SSRN Electronic Journal·2023Open Access
Breakdown of the central synapses in C9orf72-linked ALS/FTD
Frontiers in Molecular Neuroscience·2022· 16 citedOpen Access
Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis‐linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice
Glia·2022· 15 citedOpen Access
A mouse model with widespread expression of the C9orf72-linked glycine–arginine dipeptide displays non-lethal ALS/FTD-like phenotypes
Scientific Reports·2022· 26 citedOpen Access
A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes
Research Square (Research Square)·2022· 1 citedOpen Access
The effects of molecular crowding and CpG hypermethylation on DNA G-quadruplexes formed by the C9orf72 nucleotide repeat expansion
Scientific Reports·2021· 7 citedOpen Access
A Mouse Model with Widespread Expression of the C9orf72-Linked Glycine-Arginine Dipeptide Displays Non-Lethal ALS/FTD-Like Phenotypes
2021· 5 citedOpen Access
Astrocytic expression of ALS-causative mutant FUS leads to TNFα-dependent neurodegeneration <i>in vivo</i>
2021Open Access
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Frequent Co-authors

Davide Trotti(19), Piera Pasinelli(13), Brigid K. Jensen(7), M.E. Cicardi(7), Christopher J. Donnelly(6), Jeffrey D. Rothstein(6), K. Russell(6), Karthik Krishnamurthy(6), Layla Ghaffari(6), Rita Sattler(5), Xinmei Wen(5), Shashirekha S. Markandaiah(5), Kathy A. Goodson(5), Jason D. Kahn(5), Emily Welebob(5), Jiou Wang(4), Kevin McAvoy(4), Brandie Morris Verdone(4), Elizabeth L. Daley(3), Svetlana Vidensky(3)