Christopher J. Donnelly

Medicine · Health Sciences

28h-index5.8kcitations55works2.82yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(29), RNA Research and Splicing(18), Neurogenetic and Muscular Disorders Research(15), Genetic Neurodegenerative Diseases(9), Prion Diseases and Protein Misfolding(6)

Publications55 total

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
Molecular Cell·2026· 2 citedOpen Access
TDP-43 dysfunction compromises UPF1-dependent mRNA metabolism in ALS
Neuron·2025· 1 citedOpen Access
Novel Kinesin Family Member 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal Transactive Response DNA Binding Protein 43 kDa Interactions and Dendritic Atrophy
American Journal Of Pathology·2025· 2 citedOpen Access
Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD
2025· 6 citedOpen Access
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
Cell Reports·2025· 1 citedOpen Access
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
Cell Reports·2025· 9 citedOpen Access
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
2024· 4 citedOpen Access
Assays to measure small molecule Hsp70 agonist activity in vitro and in vivo
Analytical Biochemistry·2024· 2 citedOpen Access
Live-cell visualization of tau aggregation in human neurons
Communications Biology·2024· 8 citedOpen Access
Author response: CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function
2024Open Access
CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function
2024Open Access
CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function
2024· 2 citedOpen Access
CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function
2024Open Access
Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit
Neurology and Therapy·2023· 31 citedOpen Access
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
2023· 13 citedOpen Access
Disrupting pathologic phase transitions in neurodegeneration
Journal of Clinical Investigation·2023· 33 citedOpen Access
Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features
Frontiers in Cellular Neuroscience·2023· 21 citedOpen Access
Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
Molecular Neurodegeneration·2022· 44 citedOpen Access
WNK kinases sense molecular crowding and rescue cell volume via phase separation
Cell·2022· 178 citedOpen Access
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility
Nature Communications·2022· 61 citedOpen Access
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Frequent Co-authors

Amanda M. Gleixner(12), Udai Bhan Pandey(10), Rita Sattler(9), Jacob R. Mann(9), Jocelyn C. Mauna(8), Jeffery L. Twiss(7), Eric N. Anderson(7), Aaron R. Haeusler(6), Elizabeth L. Daley(6), Jeffrey D. Rothstein(6), Julia Kofler(6), James Shorter(6), Katie E. Copley(5), Bryan Hurtle(5), Sukhleen Kour(5), Evangelos Kiskinis(5), Nandini Ramesh(5), Hana M. Odeh(5), Bo Lim Lee(5), Jiou Wang(4)