Jeffrey D. Rothstein

Johns Hopkins University — United States

Medicine · Health Sciences

107h-index53.8kcitations345works8.02yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(144), Neuroscience and Neuropharmacology Research(114), Neurogenetic and Muscular Disorders Research(83), Neurogenesis and neuroplasticity mechanisms(46), Ion channel regulation and function(29)

Publications340 total

Astrocyte <scp>MCT1</scp> Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous <scp>MCT1</scp> Depletion
Glia·2025Open Access
Biobank-scale genetic characterization of Alzheimer’s disease and related dementias across diverse ancestries
Nature Communications·2025· 1 citedOpen Access
Divergent and convergent TMEM106B pathology in murine models of neurodegeneration and human disease
Acta Neuropathologica Communications·2025· 1 citedOpen Access
Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function
Nature Communications·2025· 8 citedOpen Access
The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging
Nature Medicine·2025· 48 citedOpen Access
Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data".
PubMed·2025Open Access
Efficacy and Safety of Once Daily Dosing vs. Approved On/Off Dosing of Edaravone Oral Suspension Up to 48 Weeks in Patients With Amyotrophic Lateral Sclerosis (Study <scp>MT</scp>‐1186‐<scp>A02</scp>)
Muscle & Nerve·2025· 3 citedOpen Access
Visualizing nuclear pore complex plasticity with pan-expansion microscopy
The Journal of Cell Biology·2025· 5 cited
Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects
Neuron·2025· 1 citedOpen Access
Extension Study MT-1186-A04 Evaluating Oral Edaravone (Radicava ORS®) Continued Efficacy and Safety up to an Additional 48 Weeks in Patients With ALS (P9-2.007)
Neurology·2025
Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data
Molecular & Cellular Proteomics·2025Open Access
Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling
Neurochemical Research·2025· 1 citedOpen Access
A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model
Acta Neuropathologica Communications·2024· 4 citedOpen Access
Advances in neuromuscular disorders 2024
The Lancet Neurology·2024· 2 cited
A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV- C9ORF72 (G 4 C 2 ) 66 mouse model
2024Open Access
Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human Disease
2024Open Access
Biobank-scale characterization of Alzheimer’s disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries
2024· 2 citedOpen Access
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes
Neuron·2024· 7 citedOpen Access
Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human Disease
2024· 1 citedOpen Access
Direct mitochondrial import of lactate supports resilient carbohydrate oxidation
2024· 7 citedOpen Access
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Frequent Co-authors

Nicholas J. Maragakis(7), Don W. Cleveland(6), Ralph W. Kuncl(5), Dwight E. Bergles(5), Svetlana Vidensky(5), Jonathan C. Grima(5), Leonard Petrucelli(5), Margaret Dykes‐Hoberg(4), Lee J. Martin(4), Lyle W. Ostrow(4), Juan C. Troncoso(4), Jeannie Chew(4), Jin Li(3), Donald L. Price(3), Ke Zhang(3), Christopher J. Donnelly(3), Aaron R. Haeusler(3), Kathleen M. Cunningham(3), Jiou Wang(3), Rita Sattler(3)