Matthias P. Lütolf

Roche (Switzerland) — Switzerland

Engineering · Physical Sciences

79h-index36.2kcitations289works10.42yr avg
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Research Topics

3D Printing in Biomedical Research(129), Pluripotent Stem Cells Research(60), Cancer Cells and Metastasis(47), Cellular Mechanics and Interactions(42), Tissue Engineering and Regenerative Medicine(27)

Publications289 total

Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state
Nature Communications·2025Open Access
Engineering the organoid niche to build better human models
Current Opinion in Biomedical Engineering·2025
Bioengineering mini-colons for ex vivo colorectal cancer research
Nature Protocols·2025Open Access
An integrated platform for high-throughput phenospace learning of 3D multilineage organoid systems
2025Open Access
Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model
Science Advances·2025Open Access
Unified Generation of Regionalized Neural Organoids from Single-Lumen Neuroepithelium
2025· 1 citedOpen Access
A bioengineered human urothelial organoid model reveals the urine-urothelium interplay in tissue resilience and UPEC recurrence in urinary tract infections
2025Open Access
Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic‐Fluorescence Imaging (Small Methods 10/2025)
Small Methods·2025Open Access
Epithelial tension controls intestinal cell extrusion
Science·2025· 5 citedOpen Access
Colorectal cancer heterogeneity co-evolves with tumor architecture to determine disease outcome
2025· 1 citedOpen Access
An extracellular matrix niche secreted by epithelial cells drives intestinal organoid formation
Developmental Cell·2025· 5 citedOpen Access
Morphodynamics of human early brain organoid development
Nature·2025· 30 citedOpen Access
Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic‐Fluorescence Imaging
Small Methods·2025· 1 citedOpen Access
Modeling host-microbe interactions in immunocompetent engineered human gut tissues
2025· 4 citedOpen Access
An integrated transcriptomic cell atlas of human endoderm-derived organoids
Nature Genetics·2025· 14 citedOpen Access
[Monotherapy with DOACs for patients with atrial fibrillation and stable coronary heart disease associated with lower risk than dual antithrombotic therapy].
PubMed·2025
Establishment of a microwell-array-based miniaturized thymic organoid model suitable for high-throughput applications
Cell Reports·2025· 4 citedOpen Access
394. Behavioral Characterization of OCD-Related Phenotypes in Mice With Differential Slitrk5 Deficiencies
Biological Psychiatry·2025
Accessible homeostatic gastric organoids reveal secondary cell type-specific host-pathogen interactions in Helicobacter pylori infections
Nature Communications·2025· 16 citedOpen Access
Author Correction: Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection
Nature Biomedical Engineering·2025· 1 citedOpen Access
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Frequent Co-authors

Jeffrey A. Hubbell(17), Adrian Ranga(7), Simone C. Rizzi(5), Martin Ehrbar(5), Franz E. Weber(4), Hans Clevers(4), Nicolas Broguière(4), Andreas H. Zisch(4), Helen M. Blau(3), Nikolce Gjorevski(3), Nathalie Brandenberg(3), Mehmet Girgin(3), Samy Gobaa(3), Meritxell Huch(3), Katarzyna A. Mosiewicz(3), Penney M. Gilbert(2), Hugo G. Schmoekel(2), Andrea Manfrin(2), Sonja Giger(2), Kristina Schoonjans(2)