Meritxell Huch

Cincinnati Children's Hospital Medical Center — United States

Medicine · Health Sciences

50h-index19.8kcitations126works3.02yr avg
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Research Topics

Liver physiology and pathology(45), Pancreatic function and diabetes(33), Pluripotent Stem Cells Research(17), Cancer Cells and Metastasis(15), Liver Disease Diagnosis and Treatment(14)

Publications124 total

Polygenic architecture informs potential vulnerability to drug-induced liver injury
UNC Libraries·2026Open Access
Investigating the oncogenic role of aberrant EZH2 in hepatoblastoma
Scientific Reports·2026Open Access
An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial
Nature Medicine·2026· 1 citedOpen Access
Human liver cholangiocyte organoids capture the heterogeneity of in vivo liver ductal epithelium
Cell Reports·2026Open Access
Histone Succinylation-Driven LINE-1 Reactivation Links High-Fat Diet Stress to Hepatic Inflammation and Liver Disease
2025
Human assembloids recapitulate periportal liver tissue in vitro
Nature·2025· 1 citedOpen Access
Oxygen availability and hypoxia-independent action of HIF1α controls human trophoblast maturation and function
2025Open Access
Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma
2025
Beyond the beginning – development that lasts a lifetime
Development·2025Open Access
Advances in liver and pancreas organoids: how far we have come and where we go next
Nature Reviews Gastroenterology & Hepatology·2025· 5 cited
Human assembloids recapitulate periportal liver tissue in vitro
2025· 2 citedOpen Access
Mouse liver assembloids model periportal architecture and biliary fibrosis
Nature·2025· 19 citedOpen Access
Mouse Liver Periportal Assembloids Method v1
2025· 1 citedOpen Access
Identification of hepatocyte-primed cholangiocytes in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates
Cell Reports·2025· 3 citedOpen Access
In vitro human cell-based models: What can they do and what are their limitations?
Trends in biotechnology·2024· 2 cited
Identification of PRMT5 as a therapeutic target in cholangiocarcinoma
Gut·2024· 14 citedOpen Access
In vitro human cell-based models: What can they do and what are their limitations?
Cell·2024· 6 cited
Author response: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
2024Open Access
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
eLife·2024Open Access
Author Response: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
2024Open Access
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Frequent Co-authors

Hans Clevers(25), Sylvia F. Boj(9), Monique M.A. Verstegen(9), Marc van de Wetering(9), Luc J. W. van der Laan(9), Toshiro Sato(8), Christopher J. Hindley(8), Johan H. van Es(7), Nicole Prior(7), Edwin Cuppen(6), Bon‐Kyoung Koo(6), Ruben van Boxtel(5), Helmuth Gehart(5), Jan N.M. IJzermans(5), Robert G.J. Vries(5), Benjamin D. Simons(5), Robert G. Vries(4), Pekka Kujala(4), Daniel E. Stange(4), Harry Begthel(4)