Christine Mirtsos

University Health Network — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index5.8kcitations16works0.02yr avg
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Research Topics

NF-κB Signaling Pathways(9), Immune Response and Inflammation(6), Cell death mechanisms and regulation(4), Phagocytosis and Immune Regulation(3), Immune Cell Function and Interaction(2)

Publications16 total

Regulation of death complexes formation in tumor necrosis factor receptor signaling
Experimental Cell Research·2011· 5 cited
Impaired TNFα-induced A20 expression in E1A/Ras-transformed cells
British Journal of Cancer·2009· 10 citedOpen Access
C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a
Nature·2007· 241 cited
A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
Science·2006· 110 cited
Cellular FLICE-inhibitory protein is required for T cell survival and cycling
The Journal of Experimental Medicine·2005· 78 citedOpen Access
The Role of Interleukin 1 Receptor-associated Kinase-4 (IRAK-4) Kinase Activity in IRAK-4-mediated Signaling
Journal of Biological Chemistry·2004· 137 citedOpen Access
Nur77 as a survival factor in tumor necrosis factor signaling
Proceedings of the National Academy of Sciences·2003· 81 citedOpen Access
Role of SODD in Regulation of Tumor Necrosis Factor Responses
Molecular and Cellular Biology·2003· 64 citedOpen Access
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Nature·2002· 846 cited
Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development
Immunity·2000· 507 citedOpen Access
Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling
Journal of Biological Chemistry·2000· 160 citedOpen Access
TRAF2 Deficiency Results in Hyperactivity of Certain TNFR1 Signals and Impairment of CD40-Mediated Responses
Immunity·1999· 135 citedOpen Access
Interleukin 13 Is Secreted by and Stimulates the Growth of Hodgkin and Reed-Sternberg Cells
The Journal of Experimental Medicine·1999· 282 citedOpen Access
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
Cell·1998· 2.5k citedOpen Access
The tumor suppressor gene <i>Smad4/Dpc4</i> is required for gastrulation and later for anterior development of the mouse embryo
Genes & Development·1998· 499 citedOpen Access
Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells
The Journal of Immunology·1997· 104 citedOpen Access

Frequent Co-authors

Tak W. Mak(6), Nobutaka Suzuki(6), Shinobu Suzuki(5), Andrew Wakeham(5), Annick Itié(5), Tak W. Mak(5), Wen-Chen Yeh(5), Wen‐Chen Yeh(5), Pamela S. Ohashi(4), Nien‐Jung Chen(4), Josef Penninger(3), Andrew Elia(3), José Luís de la Pompa(2), Gordon S. Duncan(2), Douglas G. Millar(2), Hidetoshi Takada(2), Michelle Ng(2), Madeleine Bonnard(2), Christian Sirard(2), Alexandra Ho(2)