Christian Sirard

Montreal Neurological Institute and Hospital — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index7.9kcitations17works0.02yr avg
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Research Topics

TGF-β signaling in diseases(4), Hematopoietic Stem Cell Transplantation(3), Chronic Myeloid Leukemia Treatments(3), Pancreatic and Hepatic Oncology Research(2), Developmental Biology and Gene Regulation(2)

Publications17 total

Smad4 and β-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2
Journal of Biological Chemistry·2003· 197 citedOpen Access
Method for validating a multi-component safety system
Safety Science·2003· 6 cited
Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes
Oncogene·2002· 26 cited
Direct Neural Fate Specification from Embryonic Stem Cells
Neuron·2001· 758 citedOpen Access
p53 Accumulation, defective cell proliferation, and early embryonic lethality in mice lacking <i>tsg101</i>
Proceedings of the National Academy of Sciences·2001· 144 citedOpen Access
Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling
Journal of Biological Chemistry·2000· 160 citedOpen Access
The tumor suppressor gene <i>Smad4/Dpc4</i> is required for gastrulation and later for anterior development of the mouse embryo
Genes & Development·1998· 499 citedOpen Access
The Interferon Regulatory Transcription Factor IRF-1 Controls Positive and Negative Selection of CD8+ Thymocytes
Immunity·1997· 114 citedOpen Access
The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse
Cell·1996· 665 citedOpen Access
Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis
Blood·1996· 191 citedOpen Access
Functional Assays for Human AML Cells by Transplantation into SCID Mice
Hämatologie und Bluttransfusion·1996
Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism
Blood·1994· 7 citedOpen Access
Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism
Blood·1994· 135 citedOpen Access
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
Nature·1994· 4.7k cited
Murine models of normal and neoplastic human haematopoiesis.
PubMed·1992· 19 cited
A Model of Human Acute Lymphoblastic Leukemia in Immune-Deficient SCID Mice
Science·1989· 242 cited
The Escherichia coli cell division mutation ftsM1 is in serU
Journal of Bacteriology·1989· 21 citedOpen Access

Frequent Co-authors

John E. Dick(7), Tsvee Lapidot(4), Tak W. Mak(4), Josef Vormoor(3), Mark D. Minden(3), Janet Rossant(3), José Luís de la Pompa(3), Andrew Wakeham(3), Barbara Murdoch(2), Trang Hoang(2), Julio Roberto Cáceres‐Cortés(2), Bruce M. Paterson(2), Michael A. Caligiuri(2), Anne Hakem(2), Andrew Elia(2), Annick Itié(2), Christine Mirtsos(2), Tak W. Mak(2), Monica Doedens(2), Pierre Laneuville(2)