Ruizhuo Lin

Northwestern Polytechnical University — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

7h-index203citations9works14.02yr avg
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Research Topics

Ubiquitin and proteasome pathways(3), Ferroptosis and cancer prognosis(3), RNA modifications and cancer(3), Toxoplasma gondii Research Studies(2), interferon and immune responses(2)

Publications9 total

Dihydroorotate dehydrogenase inhibition activates STING pathway and pyroptosis to enhance NK cell-dependent tumor immunotherapy
Molecular Biomedicine·2025· 2 citedOpen Access
Innovative PDK1‐Degrading PROTACs Transform Cancer Aerobic Glycolysis and Induce Immunogenic Cell Death in Breast Cancer
Exploration·2025· 10 citedOpen Access
Inhibition of DHODH Activates Pyroptosis and cGAS-STING Pathways to Enhance NK cell Infiltration Mediated Anti-tumor Immunity in Melanoma
2025Open Access
Organelle synergy unleashed: Modulating mitochondrial-endoplasmic reticulum contacts with a self-assembled prodrug amplifies ferroptosis for innovative cancer therapy
Chemical Engineering Journal·2024· 14 cited
A platinum(IV)–artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy
MedComm·2024· 19 citedOpen Access
A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression
Pharmacological Research·2024· 39 citedOpen Access
Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy
Acta Pharmaceutica Sinica B·2023· 42 citedOpen Access
Degradation of Hexokinase 2 Blocks Glycolysis and Induces GSDME-Dependent Pyroptosis to Amplify Immunogenic Cell Death for Breast Cancer Therapy
Journal of Medicinal Chemistry·2023· 48 cited
<b>CJ</b><sub><b>2</b></sub>: A Novel Potent Platinum(IV) Prodrug Enhances Chemo-Immunotherapy by Facilitating PD-L1 Degradation in the Cytoplasm and Cytomembrane
Journal of Medicinal Chemistry·2023· 29 cited

Frequent Co-authors

Renming Fan(9), Gaofei Wei(9), Yongrui Hai(8), Aohua Deng(7), Junyan Zhuang(7), Ruoxi Sang(3), Jiakui Gou(3), Yang Liu(3), Maosheng Cheng(3), Ting Zhao(3), Bing Qi(2), Shuo Zhang(2), Ming Zhao(2), Weike Liao(2), Siqing Fu(2), Guowen Ding(2), Bingjie Zhang(2), Yi Liu(2), Jun-Ke Song(2), Ting C. Zhao(1)