Samer O. Abdul‐Hay

Medicine · Health Sciences

16h-index788citations26works10.02yr avg
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Research Topics

Alzheimer's disease research and treatments(14), Cholinesterase and Neurodegenerative Diseases(7), Computational Drug Discovery Methods(3), Genomics, phytochemicals, and oxidative stress(3), Peptidase Inhibition and Analysis(3)

Publications26 total

Exploring the use of hybrid organic nitrates for the treatment of Alzheimer's disease.
Figshare·2025Open Access
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis
Alzheimer s Research & Therapy·2024· 20 citedOpen Access
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: Implications for Alzheimer disease pathogenesis
Research Square (Research Square)·2023Open Access
Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40
Alzheimer s Research & Therapy·2020· 74 citedOpen Access
Age and Its Association with Low Insulin and High Amyloid-β Peptides in Blood
Journal of Alzheimer s Disease·2015· 14 citedOpen Access
Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors
ACS Chemical Biology·2015· 27 citedOpen Access
P1‐055: MULTIPLE ABCA7 MISSENSE VARIANTS MINED FROM THE EXOME VARIANT SERVER SHOW INDEPENDENT ASSOCIATION WITH INCREASED OR DECREASED RISK OF LATE‐ONSET ALZHEIMER'S DISEASE (LOAD)
Alzheimer s & Dementia·2014Open Access
ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer’s disease
Molecular Neurodegeneration·2014· 81 citedOpen Access
The Blood Glucose-lowering Effect of Racecadotril is not Attributable to Inhibition of Insulin-degrading Enzyme
Hormone and Metabolic Research·2013· 1 citedOpen Access
LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer’s Disease (LOAD)
PLoS ONE·2013· 17 citedOpen Access
Optimization of Peptide Hydroxamate Inhibitors of Insulin-Degrading Enzyme Reveals Marked Substrate-Selectivity
Journal of Medicinal Chemistry·2013· 60 citedOpen Access
Quinone-Induced Activation of Keap1/Nrf2 Signaling by Aspirin Prodrugs Masquerading as Nitric Oxide
Chemical Research in Toxicology·2012· 22 cited
Identification of BACE2 as an avid ß-amyloid-degrading protease
Molecular Neurodegeneration·2012· 64 citedOpen Access
Characterization of Insulin Degrading Enzyme and Other Amyloid-β Degrading Proteases in Human Serum: A Role in Alzheimer's Disease?
Journal of Alzheimer s Disease·2012· 30 citedOpen Access
NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor
ACS Medicinal Chemistry Letters·2011· 15 citedOpen Access
O1‐05‐06: Functional cDNA screening identifies BACE‐2 as a principal beta‐amyloid degrading protease
Alzheimer s & Dementia·2011· 2 cited
Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance
PLoS ONE·2011· 117 citedOpen Access
Inhibition of Amyloidogenesis by Nonsteroidal Anti-inflammatory Drugs and Their Hybrid Nitrates
Journal of Medicinal Chemistry·2011· 32 cited
P1‐292: Correlation between insulin‐degrading enzyme levels and neuropathology in control versus Alzheimer brains with and without cerebral amyloid angiopathy
Alzheimer s & Dementia·2010
Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin
PLoS ONE·2010· 106 citedOpen Access
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Frequent Co-authors

Malcolm A. Leissring(13), Gregory R. J. Thatcher(9), Dennis W. Dickson(7), Dongcheul Kang(6), Tomoko Sahara(6), Nilüfer Ertekin‐Taner(4), Fanggeng Zou(3), Sigrid Botne Sando(3), Jan Aasly(3), Maria Barcikowska(3), Zbigniew K. Wszołek(3), Minerva M. Carrasquillo(3), Ronald C. Petersen(3), Steven G. Younkin(3), Paul Säftig(3), R. Esala P. Chandrasena(3), Shakeel Choudhry(2), Abdul H. Fauq(2), Christopher W Medway(2), Tynickwa Mims(2)