R. Esala P. Chandrasena

Chemistry · Physical Sciences

16h-index966citations28works0.02yr avg
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Research Topics

Metal-Catalyzed Oxygenation Mechanisms(10), Estrogen and related hormone effects(9), Genomics, phytochemicals, and oxidative stress(7), Porphyrin and Phthalocyanine Chemistry(6), Pharmacogenetics and Drug Metabolism(5)

Publications28 total

Supplementary Figures 1 - 6 from SERMs Attenuate Estrogen-Induced Malignant Transformation of Human Mammary Epithelial Cells by Upregulating Detoxification of Oxidative Metabolites
2023Open Access
Supplementary Figures 1 - 6 from SERMs Attenuate Estrogen-Induced Malignant Transformation of Human Mammary Epithelial Cells by Upregulating Detoxification of Oxidative Metabolites
2023Open Access
Data from SERMs Attenuate Estrogen-Induced Malignant Transformation of Human Mammary Epithelial Cells by Upregulating Detoxification of Oxidative Metabolites
2023Open Access
Data from SERMs Attenuate Estrogen-Induced Malignant Transformation of Human Mammary Epithelial Cells by Upregulating Detoxification of Oxidative Metabolites
2023Open Access
Organic Chemical Contaminants in Water System Infrastructure Following Wildfire
ACS ES&T Water·2022· 33 citedOpen Access
SERMs Attenuate Estrogen-Induced Malignant Transformation of Human Mammary Epithelial Cells by Upregulating Detoxification of Oxidative Metabolites
Cancer Prevention Research·2014· 9 citedOpen Access
Selective Estrogen Receptor Modulator (SERM) Lasofoxifene Forms Reactive Quinones Similar to Estradiol
Chemical Research in Toxicology·2012· 11 citedOpen Access
The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin
Chemico-Biological Interactions·2012· 7 citedOpen Access
Hops ( <i>Humulus lupulus</i> ) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A)
Cancer Prevention Research·2011· 46 citedOpen Access
NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor
ACS Medicinal Chemistry Letters·2011· 15 citedOpen Access
Hops (Humulus lupulus) Inhibits Estrogen Metabolism in Non-tumorigenic Human Breast Epithelial Cells (MCF-10A cells)
Planta Medica·2011
Proteomic and Mass Spectroscopic Quantitation of Protein <i>S</i> -Nitrosation Differentiates NO-Donors
ACS Chemical Biology·2010· 46 citedOpen Access
Click synthesis of estradiol–cyclodextrin conjugates as cell compartment selective estrogens
Bioorganic & Medicinal Chemistry·2009· 34 citedOpen Access
Compounds I by Photo-Oxidation of Compounds II
ECS Transactions·2009· 2 cited
Anti-Inflammatory, Antiproliferative, and Cytoprotective Activity of NO Chimera Nitrates of Use in Cancer Chemoprevention
Molecular Pharmacology·2008· 16 cited
Problematic Detoxification of Estrogen Quinones by NAD(P)H-Dependent Quinone Oxidoreductase and Glutathione-<i>S-</i>transferase
Chemical Research in Toxicology·2008· 28 cited
Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: In vitro evidence querying the NO donor functionality
Nitric Oxide·2008· 31 cited
Quinone Formation as a Chemoprevention Strategy for Hybrid Drugs: Balancing Cytotoxicity and Cytoprotection
Chemical Research in Toxicology·2007· 62 cited
Benzothiophene Selective Estrogen Receptor Modulators with Modulated Oxidative Activity and Receptor Affinity
Journal of Medicinal Chemistry·2007· 137 citedOpen Access
Products from Enzyme-Catalyzed Oxidations of Norcarenes
The Journal of Organic Chemistry·2007· 8 citedOpen Access
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Frequent Co-authors

Gregory R. J. Thatcher(16), Martin Newcomb(10), Judy L. Bolton(10), Bradley T. Michalsen(8), Robert A. Scism(6), L. P. Madhubhani P. Hemachandra(5), Hitisha Patel(5), Sujeewa C. Piyankarage(5), Shuai Wang(5), Yijin Wang(5), Emily N. Thayer(5), Marton I. Siklos(5), John H. Horner(4), Minor J. Coon(4), Paul F. Hollenberg(4), Praneeth D. Edirisinghe(4), Zhihui Qin(3), Vaishali Sinha(3), Johann Sohn(3), Teshome Gherezghiher(3)