John Spencer

East Sussex County Council — United Kingdom

Materials Science · Physical Sciences

69h-index19.6kcitations777works0.62yr avg
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Research Topics

Crystallization and Solubility Studies(170), X-ray Diffraction in Crystallography(170), Catalytic Cross-Coupling Reactions(50), Innovations in Medical Education(48), Crystallography and molecular interactions(41)

Publications773 total

The dihydropyridine LA1011 modulates multiple Hsp90—co-chaperone interactions relevant to Alzheimer’s disease
Cell Stress and Chaperones·2025Open Access
Removal of Toxic Metabolites—Chelation: Manganese Disorders
Journal of Inherited Metabolic Disease·2025Open Access
Prevalence of Pulmonary Hypertension in Individuals With Heart Failure: A Systematic Review and Meta‐Analysis
Clinical Cardiology·2025Open Access
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
Nature Communications·2025· 1 citedOpen Access
Do Demographic Factors Influence the Outcome of Guideline Directed Medical Therapy (GDMT) in Very High-Risk Atherosclerotic Cardiovascular Disease (ASCVD) Patients Seen in Private Practice?
Heart Lung and Circulation·2025Open Access
Implementing a Remote, Nurse-Led Initiative to Achieve Guideline Directed Medical Therapy (GDMT) Among Patients With Heart Failure Preserved Ejection Fraction (HFpEF) in a Large Australian Cardiology Practice
Heart Lung and Circulation·2025Open Access
Optimising LDL-C Consistent With Guideline Directed Medical Therapy (GDMT) in Patients With Very High-Risk Atherosclerotic Cardiovascular Disease (ASCVD) Utilising Natural Language Processing (NLP) to Identify Individuals Requiring Improved Lipid Lowering Therapy (LLT)
Heart Lung and Circulation·2025Open Access
A Review on Luminescent Benzoselenadiazole Derivatives: Comparison with Benzothiadiazoles, Properties, Applications, and Trends
Chemistry - An Asian Journal·2025· 3 citedOpen Access
The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
2025· 1 citedOpen Access
Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction
Royal Society Open Science·2025Open Access
Structure-guided design of ISOX-DUAL-based Degraders targeting BRD4 and CBP/EP300. A case of Degrader collapse
2025· 1 citedOpen Access
Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography
Angewandte Chemie·2025Open Access
Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography
Angewandte Chemie International Edition·2025· 6 citedOpen Access
Novel mitochondrial-targeted alkyl chains act as fungal specific inhibitors of C. neoformans
Frontiers in Microbiology·2025Open Access
Use of Aldehyde–Alkyne–Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers
ACS Medicinal Chemistry Letters·2025· 2 citedOpen Access
Characterization of the Active Enantiomer and Mapping of the Stereospecific Intermolecular Pattern of a Reference P2X7 Allosteric Antagonist
ACS Pharmacology & Translational Science·2025Open Access
Particle size effects on vapour uptake and release dynamics in metal–organic frameworks
Chemical Communications·2025· 3 citedOpen Access
Author response for "Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction"
2024
Ru(II)-Catalyzed Late-Stage C-H Amidation of Medicinally Rele-vant Benzodiazepine Scaffold
2024Open Access
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Frequent Co-authors

S Gallivan(5), Jaı̈rton Dupont(4), Tim Dornan(4), Albert Scherpbier(4), Jan Illing(4), Gill Morrow(4), Bryan Burford(4), Beate Baldauf(4), Carol Davies(4), Neil Johnson(4), Maggie Allen(4), Jill Morrison(4), Sonia Littlewood(3), Valmae Ypinazar(3), Jahangir Amin(3), Ed Peile(3), Stephen C. Robson(3), Karen Mann(2), Crestina S. Consorti(2), Thomas A. Arcury(2)