Arthur M. Doweyko

Bristol-Myers Squibb (United States) — United States

Computer Science · Physical Sciences

31h-index4.3kcitations78works0.02yr avg
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Research Topics

Computational Drug Discovery Methods(26), Melanoma and MAPK Pathways(19), Synthesis and biological activity(12), Estrogen and related hormone effects(9), Chemical Synthesis and Analysis(7)

Publications78 total

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer
ACS Medicinal Chemistry Letters·2015· 8 citedOpen Access
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists
Bioorganic & Medicinal Chemistry Letters·2015· 11 citedOpen Access
CCDC 1048587: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists
Bioorganic & Medicinal Chemistry Letters·2014· 14 citedOpen Access
Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists
Bioorganic & Medicinal Chemistry Letters·2013· 13 citedOpen Access
Synthesis and structure–activity relationships of novel indazolyl glucocorticoid receptor partial agonists
Bioorganic & Medicinal Chemistry Letters·2013· 10 citedOpen Access
The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode
Bioorganic & Medicinal Chemistry Letters·2013· 15 citedOpen Access
CCDC 922816: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
Aliens Among Us
2012
Azaxanthene Based Selective Glucocorticoid Receptor Modulators: Design, Synthesis, and Pharmacological Evaluation of (<i>S</i>)-4-(5-(1-((1,3,4-Thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5<i>H</i>-chromeno[2,3-<i>b</i>]pyridin-2-yl)-2-fluoro-<i>N</i>,<i>N</i>-dimethylbenzamide (BMS-776532) and Its Methylene Homologue (BMS-791826)
Journal of Medicinal Chemistry·2011· 55 citedOpen Access
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 13 citedOpen Access
Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists
Journal of Medicinal Chemistry·2010· 37 citedOpen Access
5-Amino-pyrazoles as potent and selective p38α inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 21 citedOpen Access
Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-<i>N</i>-propylpyrrolo[1,2-<i>f</i>][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases
Journal of Medicinal Chemistry·2010· 57 citedOpen Access
Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 31 citedOpen Access
Structure-based drug design case study: p38
Cambridge University Press eBooks·2010
What is Next for Small-Molecule Drug Discovery?
Future Medicinal Chemistry·2009· 3 cited
Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators
Bioorganic & Medicinal Chemistry Letters·2009· 20 citedOpen Access
Design, synthesis and structure–activity relationships of azole acids as novel, potent dual PPAR α/γ agonists
Bioorganic & Medicinal Chemistry Letters·2009· 35 citedOpen Access
Is QSAR relevant to drug discovery?
PubMed·2008· 9 cited
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Frequent Co-authors

Joel C. Barrish(28), Gary L. Schieven(21), Sidney Pitt(20), John H. Dodd(18), Ding Ren Shen(16), David J. Shuster(15), Kim W. McIntyre(14), John Wityak(13), John S. Sack(13), Katerina Leftheris(13), James C. Lin(11), Jagabandhu Das(10), Kathleen M. Gillooly(10), Rosemary Zhang(10), Murray McKinnon(10), Robert V. Moquin(9), Stephen T. Wrobleski(9), Susan E. Kiefer(9), Kevin Kish(9), Suhong Pang(8)