Sean Morony

Amgen (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index18.7kcitations52works0.02yr avg
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Research Topics

Bone Metabolism and Diseases(40), Bone health and treatments(29), Bone health and osteoporosis research(14), NF-κB Signaling Pathways(6), Spaceflight effects on biology(6)

Publications52 total

Osteoprotegerin is an effective countermeasure for spaceflight-induced bone loss in mice
Bone·2015· 65 citedOpen Access
Generalized Degenerative Joint Disease in Osteoprotegerin ( <i>Opg</i> ) Null Mutant Mice
Veterinary Pathology·2015· 23 cited
Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism
Bioorganic & Medicinal Chemistry Letters·2013· 8 citedOpen Access
Enhanced Mineralization Potential of Vascular Cells from SM22α-Rankl tg Mice
Calcified Tissue International·2012· 13 cited
Discovery of a Calcimimetic with Differential Effects on Parathyroid Hormone and Calcitonin Secretion
Journal of Pharmacology and Experimental Therapeutics·2011· 31 cited
CCDC 797970: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core
Bioorganic & Medicinal Chemistry Letters·2010· 10 citedOpen Access
Discovery and Optimization of Substituted 1-(1-Phenyl-1<i>H</i>-pyrazol-3-yl)methanamines as Potent and Efficacious Type II Calcimimetics
Journal of Medicinal Chemistry·2009· 17 citedOpen Access
New Variants in the <i>Enpp1</i> and <i>Ptpn6</i> Genes Cause Low BMD, Crystal-Related Arthropathy, and Vascular Calcification
Journal of Bone and Mineral Research·2009· 37 citedOpen Access
Effects of spaceflight on murine skeletal muscle gene expression
Journal of Applied Physiology·2008· 223 citedOpen Access
Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis
Journal of Bone and Mineral Research·2008· 774 cited
Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock-In Mice That Express Chimeric (Murine/Human) RANKL
Journal of Bone and Mineral Research·2008· 429 cited
Response to Letter Regarding Article, “Osteoprotegerin Inhibits Vascular Calcification Without Affecting Atherosclerosis in <i>ldlr</i> <sup>(−/−)</sup> Mice”
Circulation·2008· 18 cited
Soluble RANKL Induces High Bone Turnover and Decreases Bone Volume, Density, and Strength in Mice
Calcified Tissue International·2008· 71 cited
Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
Journal of Bone and Mineral Research·2008· 932 citedOpen Access
Osteoprotegerin Inhibits Vascular Calcification Without Affecting Atherosclerosis in <i> ldlr <sup>(−/−)</sup> </i> Mice
Circulation·2008· 252 citedOpen Access
Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis
Clinical & Experimental Metastasis·2007· 209 cited
Skeletal deterioration induced by RANKL infusion: a model for high-turnover bone disease
Osteoporosis International·2007· 32 cited
Infrequent Delivery of a Long-Acting PTH-Fc Fusion Protein Has Potent Anabolic Effects on Cortical and Cancellous Bone
Journal of Bone and Mineral Research·2007· 36 cited
Atherogenic Phospholipids Attenuate Osteogenic Signaling by BMP-2 and Parathyroid Hormone in Osteoblasts
Journal of Biological Chemistry·2007· 54 citedOpen Access
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Frequent Co-authors

Paul J. Kostenuik(26), David L. Lacey(25), Colin R. Dunstan(16), Casey Capparelli(12), Ildiko Sarosi(11), Gwyneth Van(10), Brad Bolon(9), William J. Boyle(8), Kelly Warmington(8), Zhaopo Geng(8), W. Scott Simonet(7), Ulrich Feige(7), Frank Asuncion(7), Mario Grisanti(7), Josef Penninger(6), Michael S. Ominsky(6), Marina Stolina(6), Victoria Shalhoub(6), Stephen Adamu(6), Young‐Yun Kong(5)