Mario Grisanti

Amgen (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index2.8kcitations32works0.02yr avg
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Research Topics

Bone Metabolism and Diseases(21), Bone health and treatments(18), Bone health and osteoporosis research(13), Parathyroid Disorders and Treatments(4), Wnt/β-catenin signaling in development and cancer(4)

Publications32 total

Dual Inhibition of the Wnt Inhibitors DKK1 and Sclerostin Promotes Fracture Healing and Increases the Density and Strength of Uninjured Bone
Journal of Bone and Joint Surgery·2023· 12 cited
Sclerostin Antibody Reverses Bone Loss by Increasing Bone Formation and Decreasing Bone Resorption in a Rat Model of Male Osteoporosis
Endocrinology·2017· 37 citedOpen Access
Etelcalcetide (AMG 416), a peptide agonist of the calcium-sensing receptor, preserved cortical bone structure and bone strength in subtotal nephrectomized rats with established secondary hyperparathyroidism
Bone·2017· 31 citedOpen Access
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
Nature Communications·2016· 249 citedOpen Access
Generalized Degenerative Joint Disease in Osteoprotegerin ( <i>Opg</i> ) Null Mutant Mice
Veterinary Pathology·2015· 23 cited
Progressive Increases in Bone Mass and Bone Strength in an Ovariectomized Rat Model of Osteoporosis After 26 Weeks of Treatment With a Sclerostin Antibody
Endocrinology·2014· 70 citedOpen Access
Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats
Bone·2014· 97 cited
THU0397 Increased Bone Mass and Bone Strength by Sclerostin Antibody (Scl-Ab) is Maintained by a RANKL Inhibitor in OVX Rats with Established Osteopenia
Annals of the Rheumatic Diseases·2013
Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury
Journal of Bone and Mineral Research·2011· 120 cited
Increased Bone Formation and Bone Mass Induced by Sclerostin Antibody Is Not Affected by Pretreatment or Cotreatment with Alendronate in Osteopenic, Ovariectomized Rats
Endocrinology·2011· 87 citedOpen Access
Sclerostin Inhibition by Monoclonal Antibody Accelerates the Bone Healing Process in an Ovariectomized Rat Cortical Defect Model: An in vivo microCT Study
2011· 2 cited
Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression
Annals of the Rheumatic Diseases·2010· 203 cited
Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats
Journal of Bone and Mineral Research·2010· 233 cited
Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin
Bone·2009· 68 cited
New Variants in the <i>Enpp1</i> and <i>Ptpn6</i> Genes Cause Low BMD, Crystal-Related Arthropathy, and Vascular Calcification
Journal of Bone and Mineral Research·2009· 37 citedOpen Access
One Year of Transgenic Overexpression of Osteoprotegerin in Rats Suppressed Bone Resorption and Increased Vertebral Bone Volume, Density, and Strength
Journal of Bone and Mineral Research·2009· 42 citedOpen Access
Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock-In Mice That Express Chimeric (Murine/Human) RANKL
Journal of Bone and Mineral Research·2008· 429 cited
RANKL Inhibition with Osteoprotegerin Increases Bone Strength by Improving Cortical and Trabecular bone Architecture in Ovariectomized Rats
Journal of Bone and Mineral Research·2008· 129 cited
Infrequent Delivery of a Long-Acting PTH-Fc Fusion Protein Has Potent Anabolic Effects on Cortical and Cancellous Bone
Journal of Bone and Mineral Research·2007· 36 cited
Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
Bone·2006· 429 cited
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Frequent Co-authors

Frank Asuncion(17), Michael S. Ominsky(16), Paul J. Kostenuik(14), Hua Zhu Ke(14), Xiaodong Li(14), Marina Stolina(13), W. Scott Simonet(11), Kelly Warmington(11), Denise Dwyer(11), Qing‐Tian Niu(10), Sean Morony(7), Zhaopo Geng(7), David L. Lacey(6), William G. Richards(6), Chun-Ya Han(6), Samuel S. Murray(6), Elsa J. Brochmann Murray(6), Victoria Shalhoub(5), Hong Tan(5), Mauricio Barrero(5)