Denise Dwyer

Amgen (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index5.9kcitations40works0.02yr avg
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Research Topics

Bone Metabolism and Diseases(23), Bone health and treatments(17), Bone health and osteoporosis research(15), Rheumatoid Arthritis Research and Therapies(5), Parathyroid Disorders and Treatments(4)

Publications40 total

Chamber-enriched gene expression profiles in failing human hearts with reduced ejection fraction
Scientific Reports·2021· 26 citedOpen Access
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys
Cell Reports Medicine·2021· 80 citedOpen Access
The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15
PLoS ONE·2020· 27 citedOpen Access
Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture
Regulatory Toxicology and Pharmacology·2020· 46 citedOpen Access
The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15
2020· 6 citedOpen Access
Clinically Relevant Doses of Sclerostin Antibody Do Not Induce Osteonecrosis of the Jaw (ONJ) in Rats with Experimental Periodontitis
Journal of Bone and Mineral Research·2018· 32 citedOpen Access
Serum calcium concentration is maintained when bone resorption is suppressed by osteoprotegerin in young growing male rats
Bone·2018· 6 cited
Etelcalcetide, A Novel Calcimimetic, Prevents Vascular Calcification in A Rat Model of Renal Insufficiency with Secondary Hyperparathyroidism
Calcified Tissue International·2017· 48 citedOpen Access
Etelcalcetide (AMG 416), a peptide agonist of the calcium-sensing receptor, preserved cortical bone structure and bone strength in subtotal nephrectomized rats with established secondary hyperparathyroidism
Bone·2017· 31 citedOpen Access
FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists
Journal of Bone and Mineral Research·2016· 56 citedOpen Access
FP403AMG 416, A PEPTIDE AGONIST OF THE CALCIUM-SENSING RECEPTOR, PREVENTED VASCULAR CALCIFICATION IN A RAT MODEL OF UREMIA INDUCED BY ADENINE DIET
Nephrology Dialysis Transplantation·2015Open Access
OPG-Fc but Not Zoledronic Acid Discontinuation Reverses Osteonecrosis of the Jaws (ONJ) in Mice
Journal of Bone and Mineral Research·2015· 69 citedOpen Access
Progressive Increases in Bone Mass and Bone Strength in an Ovariectomized Rat Model of Osteoporosis After 26 Weeks of Treatment With a Sclerostin Antibody
Endocrinology·2014· 70 citedOpen Access
Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats
Bone·2014· 97 cited
Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model
Journal of Orthopaedic Research®·2013· 36 cited
Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis
Annals of the Rheumatic Diseases·2013· 87 citedOpen Access
Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading
Journal of Bone and Mineral Research·2012· 143 citedOpen Access
Bone turnover markers in peripheral blood and marrow plasma reflect trabecular bone loss but not endocortical expansion in aging mice
Bone·2011· 37 cited
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
Bone·2011· 457 citedOpen Access
Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury
Journal of Bone and Mineral Research·2011· 120 cited
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Frequent Co-authors

Marina Stolina(36), Paul J. Kostenuik(22), Michael S. Ominsky(17), Xiaodong Li(15), Frank Asuncion(14), Hua Zhu Ke(14), Chun-Ya Han(12), Mario Grisanti(11), Qing‐Tian Niu(10), W. Scott Simonet(10), Kelly Warmington(8), Mauricio Barrero(7), Sean Morony(6), Debra Zack(6), William G. Richards(5), Georg Schett(5), Gwyneth Van(5), Longchuan Yu(5), Brad Bolon(5), Ulrich Feige(5)