Tomohiko Maehama

Showa University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index9.4kcitations77works1.02yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(19), Hippo pathway signaling and YAP/TAZ(17), Protein Kinase Regulation and GTPase Signaling(14), Toxin Mechanisms and Immunotoxins(9), Ubiquitin and proteasome pathways(8)

Publications77 total

Sustained YAP1 activation induces DNA demethylation that promotes the development of hepatocellular carcinomas lacking driver gene mutations
2025Open Access
MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes
Proceedings of the National Academy of Sciences·2025· 2 citedOpen Access
Nucleolar stress: Molecular mechanisms and related human diseases
Cancer Science·2023· 40 citedOpen Access
The <i>TIGD5</i> gene located in 8q24 and frequently amplified in ovarian cancers is a tumor suppressor
Genes to Cells·2022· 5 cited
<i>N</i>‐(3,4‐dimethoxyphenethyl)‐6‐methyl‐2,3,4,<scp>9‐tetrahydro‐1</scp><i>H</i>‐carbazol‐1‐amine inhibits bladder cancer progression by suppressing <scp>YAP1</scp>/<scp>TAZ</scp>
Genes to Cells·2022· 4 cited
Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers
Proceedings of the National Academy of Sciences·2022· 20 citedOpen Access
Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation
Cancer Science·2021· 27 citedOpen Access
TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands
Genes to Cells·2021· 6 citedOpen Access
The role of Hippo‐YAP signaling in squamous cell carcinomas
Cancer Science·2020· 70 citedOpen Access
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11
UNC Libraries·2020· 10 citedOpen Access
Squamous cell carcinoma onset and progression driven by multistep YAP activation
The Japanese Biochemical Society·2020
Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice
Cancer Science·2020· 35 citedOpen Access
Dynamism of PI4-Phosphate during Interactions with Human Erythrocytes in Entamoeba histolytica
Microorganisms·2020· 4 citedOpen Access
YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma
Science Advances·2020· 115 citedOpen Access
Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica
Frontiers in Cellular and Infection Microbiology·2019· 42 citedOpen Access
MOB1 regulates thymocyte egress and T‐cell survival in mice in a YAP1‐independent manner
Genes to Cells·2019· 5 citedOpen Access
Hippo pathway controls cell adhesion and context‐dependent cell competition to influence skin engraftment efficiency
The FASEB Journal·2019· 20 citedOpen Access
Loss of <i>Mob1a/b</i> in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9
Development·2018· 75 citedOpen Access
Stabilization mechanism for PICT1 oncoprotein
The Japanese Biochemical Society/The Molecular Biology Society of Japan·2017
MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation
Oncogene·2017· 54 cited
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Frequent Co-authors

Akira Suzuki(16), Miki Nishio(14), Yasunori Kanaho(14), Takehiko Sasaki(11), Jack E. Dixon(10), Hiroshi Nishina(10), Tak W. Mak(9), Koshi Mimori(8), Masakazu Yamazaki(6), Hiroshi Watanabe(6), Junji Otani(6), Michael A. Frohman(5), Hideyuki Miyazaki(5), S. Hoshino(4), Toshiaki Katada(4), Hiroki Hikasa(4), Fumiaki Okahara(4), Hirofumi Omori(4), Yosuke Miyachi(4), Kazuwa Nakao(4)