Hiroki Hikasa

University of Occupational and Environmental Health Japan — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index2.0kcitations37works1.52yr avg
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Research Topics

Wnt/β-catenin signaling in development and cancer(18), Developmental Biology and Gene Regulation(16), Hippo pathway signaling and YAP/TAZ(12), Cancer-related gene regulation(12), Cancer-related Molecular Pathways(3)

Publications37 total

MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes
Proceedings of the National Academy of Sciences·2025· 2 citedOpen Access
A highly sensitive reporter system to monitor endogenous <scp>YAP1</scp>/<scp>TAZ</scp> activity and its application in various human cells
Cancer Science·2024· 1 citedOpen Access
<i>N</i>‐(3,4‐dimethoxyphenethyl)‐6‐methyl‐2,3,4,<scp>9‐tetrahydro‐1</scp><i>H</i>‐carbazol‐1‐amine inhibits bladder cancer progression by suppressing <scp>YAP1</scp>/<scp>TAZ</scp>
Genes to Cells·2022· 4 cited
Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation
Cancer Science·2021· 27 citedOpen Access
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11
UNC Libraries·2020· 10 citedOpen Access
Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice
Cancer Science·2020· 35 citedOpen Access
YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma
Science Advances·2020· 115 citedOpen Access
Hypoxia-inducible factor-1α regulates energy fuel metabolism and mediates metabolic plasticity during ammonia stress response in ovarian cancer stem-like cells
Proceedings for Annual Meeting of The Japanese Pharmacological Society·2018Open Access
Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells
Oncotarget·2017· 34 citedOpen Access
Searching for signals controlling Hippo pathway effectors YAP/TAZ
The Japanese Biochemical Society/The Molecular Biology Society of Japan·2017
Merlin/NF2-Lin28B-let-7 Is a Tumor-Suppressive Pathway that Is Cell-Density Dependent and Hippo Independent
Cell Reports·2016· 35 citedOpen Access
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in <i>Mob1a/1b</i> -deficient mice
Proceedings of the National Academy of Sciences·2015· 192 citedOpen Access
Function of MOB1 in murine liver
The Japanese Biochemical Society/The Molecular Biology Society of Japan·2015
Merlin regulates the let-7 biogenesis via Lin28B suppression in a cell density-dependent manner
The Molecular Biology Society of Japan·2015
Wnt Signaling in Skin Development, Homeostasis,
2014
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice
Journal of Clinical Investigation·2012· 153 citedOpen Access
Wnt Signaling in Vertebrate Axis Specification
Cold Spring Harbor Perspectives in Biology·2012· 181 citedOpen Access
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11
Nature Medicine·2011· 175 citedOpen Access
Phosphorylation of TCF Proteins by Homeodomain-interacting Protein Kinase 2
Journal of Biological Chemistry·2011· 102 citedOpen Access
Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification
Developmental Cell·2010· 165 citedOpen Access
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Frequent Co-authors

Akira Suzuki(14), Sergei Y. Sokol(12), Miki Nishio(10), Masanori Taira(9), Takehiko Sasaki(7), Koshi Mimori(7), Tak W. Mak(7), Tomohiko Maehama(7), Hiroshi Nishina(6), Kohichi Kawahara(4), Junji Otani(4), Mikihito Shibata(3), Toru Nakano(3), Yoshitaka Sekido(3), Keiji Itoh(3), Shojiro Kitajima(3), K Sugimachi(2), Hiroki Goto(2), Takumi Morikawa(2), Yosuke Miyachi(2)