Joseph M. Paggi

Massachusetts Institute of Technology — United States

Neuroscience · Life Sciences

19h-index16.9kcitations40works61.02yr avg
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Research Topics

Neuropeptides and Animal Physiology(10), RNA Research and Splicing(9), Receptor Mechanisms and Signaling(9), Computational Drug Discovery Methods(8), RNA and protein synthesis mechanisms(8)

Publications40 total

Euchromatin forms condensed domains with short active regions on the surface
2025· 6 citedOpen Access
Toward decoding the mechanisms that shape sub-megabase-scale genome organization
Current Opinion in Structural Biology·2025· 2 citedOpen Access
BPS2025 - Structural basis of potassium selectivity in kalium channelrhodopsins
Biophysical Journal·2025
A non-canonical mechanism of GPCR activation
Nature Communications·2024· 19 citedOpen Access
The Art and Science of Molecular Docking
Annual Review of Biochemistry·2024· 278 citedOpen Access
Geometric Deep Learning for Structure-Based Ligand Design
ACS Central Science·2023· 41 citedOpen Access
Structural basis for ion selectivity in potassium-selective channelrhodopsins
Cell·2023· 50 citedOpen Access
A non-canonical mechanism of GPCR activation
2023· 2 citedOpen Access
How ligands achieve biased signaling at opioid receptors
Journal of Pharmacology and Experimental Therapeutics·2023Open Access
FlexVDW: A machine learning approach to account for protein flexibility in ligand docking
arXiv (Cornell University)·2023· 2 citedOpen Access
Molecular mechanism of biased signaling at the kappa opioid receptor
Nature Communications·2023· 90 citedOpen Access
Implicit Geometry and Interaction Embeddings Improve Few-Shot Molecular Property Prediction
arXiv (Cornell University)·2023Open Access
Insights into distinct signaling profiles of the µOR activated by diverse agonists
Nature Chemical Biology·2022· 115 citedOpen Access
Structural basis for ion selectivity in potassium-selective channelrhodopsins
2022· 4 citedOpen Access
Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine
Cell·2022· 142 citedOpen Access
Leveraging nonstructural data to predict structures and affinities of protein–ligand complexes
Proceedings of the National Academy of Sciences·2021· 36 citedOpen Access
Structural insights into distinct signaling profiles of the μOR activated by diverse agonists
2021· 6 citedOpen Access
Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine
2021· 17 citedOpen Access
Structural and functional characterization of G protein–coupled receptors with deep mutational scanning
eLife·2020· 166 citedOpen Access
Author response: Structural and functional characterization of G protein–coupled receptors with deep mutational scanning
2020· 1 citedOpen Access
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Frequent Co-authors

Ron O. Dror(24), Naomi R. Latorraca(8), Charu Ramakrishnan(7), Keiichi Inoue(7), Karl Deisseroth(7), Keitaro Yamashita(6), Hideaki Kato(6), Qianhui Qu(5), Brian K. Kobilka(5), Yoon Seok Kim(5), Peter Y. Wang(5), Takashi Nagata(5), Masae Konno(5), Hideki Kandori(5), Alexander S. Powers(5), AJ Venkatakrishnan(4), Koichiro Kishi(4), Masahiro Fukuda(4), Masatoshi Inoue(4), Eamon F.X. Byrne(4)