Alexander S. Powers

Washington University in St. Louis — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.6kcitations44works4.92yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Receptor Mechanisms and Signaling(8), Ion channel regulation and function(7), Protein Structure and Dynamics(6), Computational Drug Discovery Methods(6), Cannabis and Cannabinoid Research(6)

Publications44 total

A cryptic pocket in CB1 drives peripheral and functional selectivity
UNC Libraries·2025Open Access
A Graph Completion Method that Jointly Predicts Geometry and Topology Enables Effective Molecule Assembly
arXiv (Cornell University)·2025Open Access
MedSAGE: Bridging Generative AI and Medicinal Chemistry for Structure-Based Design of Small Molecule Drugs
2025· 2 citedOpen Access
Development of a G-protein Biased Peripherally Restricted Cannabinoid Receptor 1 Agonist
Journal of Pain·2025
A cryptic pocket in CB1 drives peripheral and functional selectivity
Nature·2025· 26 citedOpen Access
Targeting a Cryptic Pocket in Cannabinoid Receptor 1 Drives Peripheral and Functional Selectivity (Abstract ID: 189377)
Journal of Pharmacology and Experimental Therapeutics·2025
A non-canonical mechanism of GPCR activation
Nature Communications·2024· 19 citedOpen Access
Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR
ACS Central Science·2024· 11 citedOpen Access
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism
eLife·2024· 1 citedOpen Access
Author Response: CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism
2024Open Access
Author Response: CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism
2024Open Access
CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism
2024Open Access
Geometric Deep Learning for Structure-Based Ligand Design
ACS Central Science·2023· 41 citedOpen Access
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism
eLife·2023· 12 citedOpen Access
CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism
2023· 1 citedOpen Access
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
Nature Communications·2023· 33 citedOpen Access
MD data for "Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR".
2023Open Access
MD data for "Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR".
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism
2023Open Access
A non-canonical mechanism of GPCR activation
2023· 2 citedOpen Access
page 1 of 3Next →

Frequent Co-authors

Ron O. Dror(31), Grigore Pintilie(8), Wah Chiu(8), Mengyuan Xu(7), Torben R. Neelands(7), Yan Liu(7), S. D. Miller(7), J. Du Bois(7), Merritt Maduke(7), A. Paul Alivisatos(5), Kaavya Krishna Kumar(5), Brian K. Kobilka(5), Yianni Laloudakis(5), Joseph M. Paggi(5), Susruta Majumdar(5), Vi Pham(4), Steven M. Paul(4), Arthur Christopoulos(4), David M. Thal(4), Christian C. Felder(4)