James P. Apland

United States Army — United States

Agricultural and Biological Sciences · Life Sciences

22h-index1.3kcitations49works0.02yr avg
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Research Topics

Pesticide Exposure and Toxicity(23), Neuroscience and Neuropharmacology Research(19), Botulinum Toxin and Related Neurological Disorders(10), Memory and Neural Mechanisms(9), Insect and Pesticide Research(8)

Publications49 total

Preventing Long-Term Brain Damage by Nerve Agent–Induced Status Epilepticus in Rat Models Applicable to Infants: Significant Neuroprotection by Tezampanel Combined with Caramiphen but Not by Midazolam Treatment
Journal of Pharmacology and Experimental Therapeutics·2023· 8 citedOpen Access
Delayed tezampanel and caramiphen treatment but not midazolam protects against long-term neuropathology after soman exposure
Experimental Biology and Medicine·2023· 9 citedOpen Access
Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus
Toxics·2022· 13 citedOpen Access
Acetylcholinesterase inhibitors (nerve agents) as weapons of mass destruction: History, mechanisms of action, and medical countermeasures
Neuropharmacology·2020· 115 cited
Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4
Archives of Toxicology·2020· 5 cited
Electroencephalographic analysis in soman‐exposed 21‐day‐old rats and the effects of midazolam or LY293558 with caramiphen
Annals of the New York Academy of Sciences·2020· 15 cited
Pyridostigmine Protection from Nerve Agent Intoxication: Concept to FDA Approval *
2019· 1 cited
Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy
Neurobiology of Disease·2019· 52 citedOpen Access
Acute and long‐term consequences of exposure to organophosphate nerve agents in humans
Epilepsia·2018· 137 citedOpen Access
Full Protection Against Soman-Induced Seizures and Brain Damage by LY293558 and Caramiphen Combination Treatment in Adult Rats
Neurotoxicity Research·2018· 24 cited
Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population
Journal of Pharmacology and Experimental Therapeutics·2018· 11 citedOpen Access
Susceptibility to Soman Toxicity and Efficacy of LY293558 Against Soman-Induced Seizures and Neuropathology in 10-Month-Old Male Rats
Neurotoxicity Research·2017· 14 cited
The M1 Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala
Journal of Pharmacology and Experimental Therapeutics·2016· 28 citedOpen Access
Long‐term neuropathological and behavioral impairments after exposure to nerve agents
Annals of the New York Academy of Sciences·2016· 48 citedOpen Access
Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure
NeuroMolecular Medicine·2015· 19 cited
A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists
Toxicology and Applied Pharmacology·2015· 24 cited
LY293558 prevents soman-induced pathophysiological alterations in the basolateral amygdala and the development of anxiety
Neuropharmacology·2014· 27 citedOpen Access
The Limitations of Diazepam as a Treatment for Nerve Agent–Induced Seizures and Neuropathology in Rats: Comparison with UBP302
Journal of Pharmacology and Experimental Therapeutics·2014· 67 citedOpen Access
Pathophysiological mechanisms underlying increased anxiety after soman exposure: Reduced GABAergic inhibition in the basolateral amygdala
NeuroToxicology·2014· 40 citedOpen Access
The recovery of acetylcholinesterase activity and the progression of neuropathological and pathophysiological alterations in the rat basolateral amygdala after soman-induced status epilepticus: Relation to anxiety-like behavior
Neuropharmacology·2014· 59 citedOpen Access
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Frequent Co-authors

Maria F. M. Braga(26), Vassiliki Aroniadou‐Anderjaska(25), Taíza H. Figueiredo(24), Michael Adler(10), Felicia Qashu(7), Eric M. Prager(7), Volodymyr I. Pidoplichko(6), Marcio de Araujo Furtado(4), Steven L. Miller(4), Sharad S. Deshpande(4), Margaret G. Filbert(4), Camila P. Almeida-Suhett(3), George A. Oyler(3), Katia Rossetti(3), Ann M. Marini(2), Adriana Pereira de Souza(2), Franco Rossetti(2), Cara Olsen(2), Teresa M. Ferrara(2), Antonio Ferrer‐Montiel(2)