Matthias Megges

Charité - Universitätsmedizin Berlin — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index921citations28works4.72yr avg
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Research Topics

Pluripotent Stem Cells Research(9), Mesenchymal stem cell research(5), RNA Research and Splicing(4), Tissue Engineering and Regenerative Medicine(4), Thyroid Disorders and Treatments(3)

Publications28 total

Correction of the Allan-Herndon-Dudley syndrome-causing SLC16A2 mutation G401R in a patient derived hiPSC line
Stem Cell Research·2025Open Access
RNA Sequencing Reveals a Strong Predominance of THRA Splicing Isoform 2 in the Developing and Adult Human Brain
International Journal of Molecular Sciences·2024· 3 citedOpen Access
Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development
Scientific Reports·2024· 11 citedOpen Access
RNA-sequencing reveals strong predominance of <i>THRA</i> splicing isoform 2 in the developing and adult human brain
2023· 2 citedOpen Access
Generation of iPSC lines with SLC16A2:G401R or SLC16A2 knock out
Stem Cell Research·2023· 4 citedOpen Access
Spatiotemporal expression of thyroid hormone transporter MCT8 and <i>THRA</i> mRNA in human cerebral organoids recapitulating first trimester cortex development
2023· 2 citedOpen Access
Development of an image-based method for spatial registration of T3-induced changes in cell types and gene expression in human cerebral organoids
Endocrine Abstracts·2023
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment
Science Translational Medicine·2023· 16 cited
An experimental framework for probing molecular mechanisms of local thyroid hormone action during cortical neurogenesis in human cerebral organoids
Endocrine Abstracts·2022
A single cell atlas of the T3-responsive transcriptome during early cortical neurogenesis in human cerebral organoids
Endocrine Abstracts·2022
Spatiotemporal expression of the thyroid hormone transporter MCT8 during cortical neurogenesis in human cerebral organoids
Endocrine Abstracts·2022
Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
Stem Cell Research & Therapy·2019· 140 citedOpen Access
Transplanted Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Support Liver Regeneration in Gunn Rats
Stem Cells and Development·2018· 25 citedOpen Access
Analysis of the applicability of iPS cell-based approaches to bypass senescence and to re-establish rejuvenation features in human MSCs from aged individuals
2016Open Access
Episomal plasmid-based generation of induced pluripotent stem cells from fetal femur-derived human mesenchymal stromal cells
Stem Cell Research·2015· 8 citedOpen Access
Regenerative potential of human pluripotent stem cell-derived MSCs in a Gunn rat liver injury model
Zeitschrift für Gastroenterologie·2015
Generation of an iPS cell line from bone marrow derived mesenchymal stromal cells from an elderly patient
Stem Cell Research·2015· 8 citedOpen Access
Erratum: Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks
BMC Genomics·2015· 14 citedOpen Access
Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networks
BMC Genomics·2015· 138 citedOpen Access
Apc and p53 interaction in DNA damage and genomic instability in hepatocytes
Oncogene·2014· 25 citedOpen Access
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Frequent Co-authors

James Adjaye(11), Robert Opitz(11), Harald Stachelscheid(9), Peter Kühnen(9), Valeria Fernández Vallone(7), Alessandro Prigione(5), Wasco Wruck(5), Amir M. Hossini(5), Evgenia Makrantonaki(5), Christos C. Zouboulis(5), Richard O. C. Oreffo(4), Mohammad R. Toliat(3), Hans Lehrach(3), Julia Luther(3), Frank Drießler(3), A. Reichardt(3), Jean‐Pierre David(3), Audrey Amber Julie Bresser(3), Benedikt Obermayer-Wasserscheid(3), Julie Bresser Audrey Amber(3)