Damiano Cosimo Rigiracciolo

University of California, San Diego — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index1.9kcitations44works4.62yr avg
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Research Topics

Estrogen and related hormone effects(12), Hippo pathway signaling and YAP/TAZ(8), Cancer Cells and Metastasis(5), Cell Adhesion Molecules Research(5), Epigenetics and DNA Methylation(4)

Publications44 total

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma
Cancer Cell·2025· 22 cited
Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis
Nature Communications·2024· 8 citedOpen Access
767 Analysis of antitumor immune responses induced by simvastatin plus anti-PD1 in mice and human melanomas
Regular and Young Investigator Award Abstracts·2024Open Access
Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitry
2024Open Access
Abstract 6991: Transcriptomic profiling of human and mouse models highlights YAP pathway hyperactivation as the underlying mechanism of the biological and clinical aggressiveness of Numb-defective bladder cancer
Cancer Research·2024
Abstract 4745: A novel combination therapy targeting RAF, MEK and FAK to overcome skin cutaneous melanoma treatment resistance
Cancer Research·2024· 2 cited
Targeting systems vulnerabilities in uveal melanoma by CRISPR Cas/9 focal adhesion kinase (FAK) genome editing and therapeutic inhibition
Archive of Doctoral Theses and Digital Collections (University of Calabria)·2024Open Access
High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
Cell Reports Medicine·2023· 23 citedOpen Access
GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathway
Cell Death Discovery·2023· 18 citedOpen Access
Publisher Correction: RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer
Breast Cancer Research·2023· 3 citedOpen Access
RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer
Breast Cancer Research·2023· 7 citedOpen Access
The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of RAGE-prompted motility of breast cancer cells
Journal of Experimental & Clinical Cancer Research·2023· 13 citedOpen Access
Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry
Journal of Biological Chemistry·2022· 16 citedOpen Access
Metformin counteracts stimulatory effects induced by insulin in primary breast cancer cells
Journal of Translational Medicine·2022· 26 citedOpen Access
Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC)
Journal of Experimental & Clinical Cancer Research·2022· 68 citedOpen Access
G-Protein-Coupled Estrogen Receptor Expression in Rat Uterine Artery Is Increased by Pregnancy and Induces Dilation in a Ca2+ and ERK1/2 Dependent Manner
International Journal of Molecular Sciences·2022· 13 citedOpen Access
Assessment of androgen receptor, IGF-IR and insulin receptor expression in male patients with severe peripheral artery disease
Heliyon·2022· 1 citedOpen Access
Estrogen receptor variant ERα46 and insulin receptor drive in primary breast cancer cells growth effects and interleukin 11 induction prompting the motility of cancer‐associated fibroblasts
Clinical and Translational Medicine·2021· 28 citedOpen Access
Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression
Cancers·2021· 50 citedOpen Access
Correction: Rigiracciolo, D.C., et al., IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Cells 2020, 9, 1010
Cells·2020· 14 citedOpen Access
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Frequent Co-authors

Marcello Maggiolini(35), Rosamaria Lappano(25), Francesca Cirillo(21), Ernestina Marianna De Francesco(19), Antonino Belfiore(15), Marianna Talia(13), J. Silvio Gutkind(11), Maria Francesca Santolla(11), Domenica Scordamaglia(9), Nadia Arang(8), Simone Lubrano(8), Adele Vivacqua(8), Paola De Marco(7), Michele Pellegrino(7), Lucia Muglia(7), Anna Miglietta(7), Silvia Avino(6), Jonathan A. Pachter(5), Andrea Scarpelli(5), Anna Rita Cappello(4)