Sanford L. Boye

University of Florida Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

60h-index12.9kcitations375works8.32yr avg
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Research Topics

Retinal Development and Disorders(185), Virus-based gene therapy research(80), Retinal Diseases and Treatments(75), CRISPR and Genetic Engineering(43), Photoreceptor and optogenetics research(39)

Publications280 total

Development of an AAV-based gene therapy for the ocular phenotype of Friedreich’s ataxia
Molecular Therapy·2025Open Access
A novel multiplex RNAi therapy simultaneously targets Hif1a and Hif2a to defy retinal degeneration in two models of AMD
Molecular Therapy·2025Open Access
Assessment of the Orbit® subretinal delivery system (Orbit® SDS device) and prototypes in adult and juvenile canine eyes
Drug Delivery and Translational Research·2025· 1 citedOpen Access
Quantifying DNA point mutations in commercially available AAV reporter vectors and plasmids
Molecular Therapy — Methods & Clinical Development·2025Open Access
Current clinical applications of AAV-mediated gene therapy
Molecular Therapy·2025· 35 citedOpen Access
A Comprehensive Review of Clinically Applied Adeno-Associated Virus-Based Gene Therapies for Ocular Disease
Human Gene Therapy·2025· 6 cited
Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs
Translational Vision Science & Technology·2024· 7 citedOpen Access
A novel multiplex RNAi therapy simultaneously targets <i>Hif1a</i> and <i>Hif2a</i> to defy retinal degeneration in two models of AMD
2024· 1 citedOpen Access
Safety and improved efficacy signals following gene therapy in childhood blindness caused by GUCY2D mutations
iScience·2024· 1 citedOpen Access
TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development
Communications Biology·2024· 5 citedOpen Access
Engineered AAV capsid transport mutants overcome transduction deficiencies in the aged CNS
Molecular Therapy — Nucleic Acids·2024· 6 citedOpen Access
Safety and efficacy of ATSN-101 in patients with Leber congenital amaurosis caused by biallelic mutations in GUCY2D: a phase 1/2, multicentre, open-label, unilateral dose escalation study
The Lancet·2024· 28 cited
Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin‐protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide‐gated channel deficiency
The FASEB Journal·2024· 3 citedOpen Access
Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion
Molecular Therapy·2023· 18 citedOpen Access
Dual-AAV vector-mediated expression of MYO7A improves vestibular function in a mouse model of Usher syndrome 1B
Molecular Therapy — Methods & Clinical Development·2023· 19 citedOpen Access
Correction: Site-specific modifications to AAV8 capsid yields enhanced brain transduction in the neonatal MPS IIIB mouse
Gene Therapy·2023Open Access
Development of an AAV-CRISPR-Cas9-based treatment for dominant cone-rod dystrophy 6
Molecular Therapy — Methods & Clinical Development·2023· 6 citedOpen Access
Improving retinal vascular endothelial cell tropism through rational rAAV capsid design
PLoS ONE·2023· 1 citedOpen Access
Intravitreal Administration of AAV2-SIRT1 Reverses Diabetic Retinopathy in a Mouse Model of Type 2 Diabetes
Translational Vision Science & Technology·2023· 11 citedOpen Access
β-secretase 1 overexpression by AAV-mediated gene delivery prevents retina degeneration in a mouse model of age-related macular degeneration
Molecular Therapy·2023· 9 citedOpen Access
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Frequent Co-authors

William W. Hauswirth(43), Samuel G. Jacobson(11), Artur V. Cideciyan(10), Thomas J. Conlon(10), Jijing Pang(9), Vince A. Chiodo(9), Tomás S. Alemán(8), Sharon Schwartz(7), Alejandro J. Román(7), Alexander Sumaroka(7), Alfred S. Lewin(7), Frank M. Dyka(7), Shalesh Kaushal(6), Barry J. Byrne(6), William A. Beltran(6), Wen‐Tao Deng(6), Renee C. Ryals(6), Gustavo D. Aguirre(5), Kirsten Erger(5), Yumiko Umino(5)