Matt Griffor

Pfizer (United States) — United States

Medicine · Health Sciences

10h-index1.8kcitations19works2.02yr avg
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Research Topics

HER2/EGFR in Cancer Research(8), DNA Repair Mechanisms(3), Cancer therapeutics and mechanisms(3), Protease and Inhibitor Mechanisms(2), Cell Adhesion Molecules Research(2)

Publications19 total

Discovery, Characterization, and Structure of a Cell Active PAD2 Inhibitor Acting through a Novel Allosteric Mechanism
ACS Chemical Biology·2024· 2 cited
Data from Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271
2023Open Access
Supplementary Data from Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271
2023Open Access
Data from Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271
2023Open Access
Supplementary Data from Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271
2023Open Access
The catalytic mechanism of cyclic GMP‐AMP synthase (cGAS) and implications for innate immunity and inhibition
Protein Science·2017· 65 citedOpen Access
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
Scientific Reports·2016· 55 citedOpen Access
Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro
Chemistry & Biology·2014· 72 cited
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
Journal of Biological Chemistry·2010· 889 citedOpen Access
Abstract A86: Design, synthesis, and SAR of focal adhesion kinase (FAK) inhibitors
Molecular Cancer Therapeutics·2009· 2 cited
Structure of the adenylation domain of NAD<sup>+</sup>-dependent DNA ligase from<i>Staphylococcus aureus</i>
Acta Crystallographica Section F Structural Biology and Crystallization Communications·2009· 13 citedOpen Access
Crystal structure of the adenylation domain of NAD+-dependent DNA ligase from Staphylococcus aureus
2009
Selective Inhibition of Casein Kinase 1ϵ Minimally Alters Circadian Clock Period
Journal of Pharmacology and Experimental Therapeutics·2009· 177 cited
Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design
Journal of Biological Chemistry·2009· 107 citedOpen Access
Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271
Cancer Research·2008· 379 citedOpen Access
Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Å resolution
Protein Science·2007· 32 citedOpen Access
Design, synthesis, activity and properties of selective inhibitors of focal adhesion kinase.
Cancer Research·2006
human SDH/NAD+ complex
2003
Cloning and Functional Characterization of an NAD <sup>+</sup> -Dependent DNA Ligase from <i>Staphylococcus aureus</i>
Journal of Bacteriology·2001· 51 citedOpen Access

Frequent Co-authors

W. Gregory Roberts(7), Ethan Ung(7), Pamela Whalen(7), Catherine A. Hulford(7), John C. Kath(7), Eric S. Marr(7), F.F. Vajdos(7), Luis Martinez-Alsina(6), Marianne Lorenzen(6), Martin A. Berliner(6), Michael J. Luzzio(6), Nandini C. Patel(6), Susan LaGreca(6), Jitesh P. Jani(6), Christofer Autry(5), Earling Emerson(5), Matt Wessel(5), Boris A. Chrunyk(4), Jeanne S. Chang(4), Beth A. Cooper(4)