Joshua McElwee

Intarcia Therapeutics (United States) — United States

Immunology and Microbiology · Life Sciences

34h-index10.2kcitations62works0.02yr avg
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Research Topics

Immunodeficiency and Autoimmune Disorders(14), Genetics, Aging, and Longevity in Model Organisms(13), T-cell and B-cell Immunology(11), Immune Cell Function and Interaction(9), Mitochondrial Function and Pathology(5)

Publications62 total

Structurally Enabling ADMET Anti-Targets via Induced Fit Docking and Free Energy Perturbation
2026Open Access
Structurally Enabling ADMET Anti-Targets via Induced Fit Docking and Free Energy Perturbation
2026Open Access
TARGETING SELECTIVE TYROSINE KINASE 2 (TYK2) INHIBITORS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
Medicinal chemistry reviews·2023
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279
Journal of Medicinal Chemistry·2023· 48 citedOpen Access
Discovery and characterization of novel inhibitors of CTP synthase 1 (CTPS1) for the treatment of autoimmune and inflammatory disease
The Journal of Immunology·2023· 2 citedOpen Access
Genetically defined individual reference ranges for tryptase limit unnecessary procedures and unmask myeloid neoplasms
Blood Advances·2022· 53 citedOpen Access
33226 Analysis of histologic and molecular improvement in moderate-to-severe psoriasis: Results from a phase 1b trial of the novel allosteric Tyk2 inhibitor NTX-973
Journal of the American Academy of Dermatology·2022· 6 cited
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
Bioorganic & Medicinal Chemistry Letters·2022· 15 citedOpen Access
Structural basis for isoform-specific inhibition of human CTPS1
Proceedings of the National Academy of Sciences·2021· 44 citedOpen Access
Abstract 1649: Mechanistic understanding of HPK1 inhibition on enhanced human T cell activation and tumor immunity in a syngeneic model
Cancer Research·2021· 1 cited
685 A highly selective and potent HPK1 inhibitor enhances immune cell activation and induces robust tumor growth inhibition in a murine syngeneic tumor model
Regular and Young Investigator Award Abstracts·2020· 1 citedOpen Access
Insights into dispersed duplications and complex structural mutations from whole genome sequencing 706 families
2020Open Access
Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology
Nature Communications·2019· 82 citedOpen Access
Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase
Frontiers in Immunology·2019· 14 citedOpen Access
Phenome-wide association studies across large population cohorts support drug target validation
Nature Communications·2018· 191 citedOpen Access
A missense mutation impairs ITK function in a patient with severe Epstein-Barr virus disease.
The Journal of Immunology·2018· 1 cited
Genetic and Structural Analysis of a SKIV2L Mutation Causing Tricho-hepato-enteric Syndrome
Digestive Diseases and Sciences·2018· 15 citedOpen Access
A Pope Francis Lexicon
Project Muse (Johns Hopkins University)·2018
Phenome-wide association studies across large population cohorts support drug target validation
RePEc: Research Papers in Economics·2018Open Access
Phenome-wide association studies (PheWAS) across large “real-world data” population cohorts support drug target validation
2017· 8 citedOpen Access
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Frequent Co-authors

Yu Zhang(13), Jason D. Hughes(12), Helen Matthews(12), Helen C. Su(10), David Gems(10), Joshua D. Milner(9), Jonathan J. Lyons(9), Julie E. Niemela(6), Michael J. Lenardo(6), Thomas DiMaggio(6), V. Koneti Rao(5), Steven M. Holland(5), Michael P. O’Connell(5), Eugene F. Schuster(5), Celeste Nelson(5), Kelly D. Stone(5), Neelu Kaila(5), Susan Price(4), Matthew D. W. Piper(4), Linda Partridge(4)