Susana Liu

Queen's University — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index2.0kcitations25works13.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(15), Phosphodiesterase function and regulation(15), Cholinesterase and Neurodegenerative Diseases(12), Renin-Angiotensin System Studies(5), Hormonal Regulation and Hypertension(4)

Publications25 total

The Versatile and Strategic <i>O</i>-Carbamate Directed Metalation Group in the Synthesis of Aromatic Molecules: An Update
Chemical Reviews·2024· 13 citedOpen Access
Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines
Bioorganic & Medicinal Chemistry Letters·2011· 17 citedOpen Access
Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of tertiary alcohol-bearing piperidines
Bioorganic & Medicinal Chemistry Letters·2011· 15 citedOpen Access
Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors
Journal of the Renin-Angiotensin-Aldosterone System·2011· 5 citedOpen Access
Pharmacological and genetic evidence that cathepsin B is not the physiological activator of rodent prorenin
Biological Chemistry·2010· 3 cited
Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment
Bioorganic & Medicinal Chemistry Letters·2010· 43 citedOpen Access
The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 22 citedOpen Access
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 2 citedOpen Access
Development of a homogeneous immunoassay for the detection of angiotensin I in plasma using AlphaLISA acceptor beads technology
Analytical Biochemistry·2009· 33 cited
Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors
Bioorganic & Medicinal Chemistry Letters·2008· 12 citedOpen Access
Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 3 citedOpen Access
Preferential inhibition of human phosphodiesterase 4 by ibudilast
Life Sciences·2005· 60 cited
Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor
Bioorganic & Medicinal Chemistry Letters·2005· 30 citedOpen Access
Dynamic Activation of Cystic Fibrosis Transmembrane Conductance Regulator by Type 3 and Type 4D Phosphodiesterase Inhibitors
Journal of Pharmacology and Experimental Therapeutics·2005· 58 cited
Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis
Journal of Clinical Investigation·2002· 266 citedOpen Access
Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis
Journal of Clinical Investigation·2002· 258 cited
Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis
Journal of Clinical Investigation·2002· 33 citedOpen Access
In vitro PKA phosphorylation‐mediated human PDE4A4 activation
FEBS Letters·2002· 24 citedOpen Access
Dissecting the Cofactor-Dependent and Independent Bindings of PDE4 Inhibitors
Biochemistry·2001· 56 cited
Hunting the Emesis and Efficacy Targets of PDE4 Inhibitors:  Identification of the Photoaffinity Probe 8-(3-Azidophenyl)-6- [(4-iodo-1<i>H</i>-1-imidazolyl)methyl]quinoline (APIIMQ)
Journal of Medicinal Chemistry·2000· 30 citedOpen Access
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Frequent Co-authors

Zheng Huang(14), France Laliberté(13), Dwight Macdonald(11), Daniel Dubé(9), Patrick Lacombe(7), Michael J. Gresser(6), Michel Gallant(6), Yves Girard(6), Jean-François Lévesque(5), Joseph A. Mancini(5), Donald W. Nicholson(5), Angela Styhler(5), Robert N. Young(5), M. David Percival(5), Denis Deschênes(5), P. Masson(5), Annette Robichaud(4), Myriam Salem(4), Stephen H. Day(4), Hélène Perrier(4)