Daniel Dubé

Chemical Synthesis Lab — Singapore

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index2.0kcitations55works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(12), Phosphodiesterase function and regulation(10), Cholinesterase and Neurodegenerative Diseases(9), Inflammatory mediators and NSAID effects(6), Renin-Angiotensin System Studies(6)

Publications55 total

Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine
Organic Letters·2017· 21 citedOpen Access
CCDC 1580237: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1580236: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1580234: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1580233: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1580238: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1580235: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
3,4-Diarylpiperidines as potent renin inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 9 citedOpen Access
Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents
Bioorganic & Medicinal Chemistry Letters·2011· 13 cited
Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines
Bioorganic & Medicinal Chemistry Letters·2011· 17 citedOpen Access
Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of tertiary alcohol-bearing piperidines
Bioorganic & Medicinal Chemistry Letters·2011· 15 citedOpen Access
The discovery and synthesis of potent zwitterionic inhibitors of renin
Bioorganic & Medicinal Chemistry Letters·2011· 10 citedOpen Access
Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment
Bioorganic & Medicinal Chemistry Letters·2010· 43 citedOpen Access
Identification of a new biaryl scaffold generating potent renin inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 9 citedOpen Access
The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 22 citedOpen Access
Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study
Bioorganic & Medicinal Chemistry Letters·2010· 16 citedOpen Access
Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension
Bioorganic & Medicinal Chemistry Letters·2010· 17 citedOpen Access
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 2 citedOpen Access
Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors
Bioorganic & Medicinal Chemistry Letters·2008· 12 citedOpen Access
L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition
Biochemical Pharmacology·2007· 30 cited
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Frequent Co-authors

Yves Girard(18), Michel Gallant(14), Patrick Lacombe(14), Dwight Macdonald(13), Richard W. Friesen(11), Robert N. Young(11), Jean‐Pierre Falgueyret(10), Denis Riendeau(9), Christine Brideau(9), Denis Deschênes(9), Susana Liu(9), Zheng Huang(9), Jean-François Lévesque(9), Joseph A. Mancini(8), Réjean Fortin(8), Stephen Hanessian(8), Yves Ducharme(8), France Laliberté(8), Erich L. Grimm(8), Paul J. Hodges(7)