William C. Mobley

University of California San Diego — United States

Medicine · Health Sciences

83h-index24.2kcitations322works2.92yr avg
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Research Topics

Down syndrome and intellectual disability research(84), Nerve injury and regeneration(66), Alzheimer's disease research and treatments(61), Neurogenesis and neuroplasticity mechanisms(32), Genetics and Neurodevelopmental Disorders(29)

Publications322 total

Stereology with OPEN-Stereo: low-cost, accessible, and accurate cellular quantification
Scientific Reports·2025Open Access
RAB5 Hyperactivation Induces APP‐Driven Endolysosomal and Autophagic Dysfunction in Down Syndrome: Reversal by Antisense Oligonucleotides Targeting <i>App</i> and <i>Rab5</i>
Alzheimer s & Dementia·2025Open Access
Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology
Annals of Neurology·2025Open Access
Tau pathology differs by sex in Alzheimer's disease in Down syndrome
Alzheimer s & Dementia·2025Open Access
The history of Down syndrome–associated Alzheimer's disease; past, present, and future
Alzheimer s & Dementia·2025· 10 citedOpen Access
Correction: An Anti-β-Amyloid vaccine for treating cognitive deficits in a mouse model of down syndrome
PLoS ONE·2025Open Access
Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased <i>APP</i> gene dose
Alzheimer s & Dementia·2025· 5 citedOpen Access
Antisense oligonucleotides directed against <i>App</i> and <i>Rab5</i> normalized endosomal Rab activity and reversed DS‐AD‐linked degenerative phenotypes in the Dp16 mouse model of Down syndrome
Alzheimer s & Dementia·2025· 5 citedOpen Access
Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society
NeuroMolecular Medicine·2025Open Access
Down Syndrome: Progress in Defining Pathogenesis and Treatments for Neurodevelopmental Deficits and Alzheimer’s Disease
Translational Neuroscience·2025Open Access
Human iPSC‐derived neuron modeling for the study of early‐onset Alzheimer’s disease
Alzheimer s & Dementia·2024Open Access
Antisense‐mediated APP suppression as potential therapeutic for Down Syndrome Alzheimer’s Disease
Alzheimer s & Dementia·2024Open Access
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis
Neuron·2024
The Role of Biomedical and Pharmaceutical Sciences in Pharmacy Education and Practice
American Journal of Pharmaceutical Education·2024· 4 citedOpen Access
I feel your pain: higher empathy is associated with higher posterior default mode network activity
Pain·2024· 4 cited
The Leicester empathy declaration: A model for implementing empathy in healthcare
Patient Education and Counseling·2024· 1 citedOpen Access
Author response: Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling
2024· 1 citedOpen Access
Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling
eLife·2024Open Access
Author response: Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling
2024Open Access
Reviewer #1 (Public Review): Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling
2024Open Access
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Frequent Co-authors

Pavel V. Belichenko(11), Alexander M. Kleschevnikov(9), Chengbiao Wu(8), Ahmad Salehi(7), J Valletta(7), Charles J. Epstein(7), Charles L. Howe(5), Jonathan D. Cooper(4), Jean‐Dominique Delcroix(3), Ryoko Takimoto‐Kimura(3), Angela J. Villar(3), Michael V. Johnston(3), Joshua F. Kilbridge(3), Jane Chua-Couzens(3), Elaine J. Carlson(3), Eric C. Beattie(3), Eliezer Masliah(3), Mehrdad Faizi(3), Mehrdad Shamloo(3), Ralph A. Nixon(2)