Michael F. Princiotta

Fulcrum Therapeutics (United States) — United States

Immunology and Microbiology · Life Sciences

21h-index3.8kcitations63works0.52yr avg
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Research Topics

Immunotherapy and Immune Responses(38), vaccines and immunoinformatics approaches(17), Immune Cell Function and Interaction(14), T-cell and B-cell Immunology(13), Cancer Immunotherapy and Biomarkers(10)

Publications61 total

CBX–663, a novel TCR-mimetic T-cell engager targeting a telomerase reverse transcriptase (TERT) peptide-HLA complex, that exhibits potent efficacy against AML cells
Blood·2025
Abstract 3507: Discovery and preclinical characterization of novel TCR-mimetic T-cell engagers targeting TERT peptide-HLA complex for the treatment of solid and hematologic malignancies
Cancer Research·2025
CBX250 Is a Novel Cathepsin G Peptide-HLA-Targeting T Cell Engager That Exhibits High Tumor Antigen Selectivity and Potent Antileukemic Activity In Vivo
Blood·2024· 1 citedOpen Access
Abstract 1236: Characterization of CBX-250, a first-in-class TCR-mimetic-based T-cell engager targeting a cathepsin G peptide-HLA complex for the treatment of myeloid leukemia
Cancer Research·2024· 1 cited
Figure S3 from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
2023Open Access
Supplemental Material and Methods from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
2023Open Access
Data from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
2023Open Access
Data from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
2023Open Access
Figure S1 from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
2023Open Access
Figure S2 from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
2023Open Access
Figure S1 from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
2023Open Access
Supplemental Material and Methods from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
2023Open Access
Figure S3 from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
2023Open Access
Figure S2 from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
2023Open Access
Neoantigen-based personalized cancer vaccines: the emergence of precision cancer immunotherapy
Expert Review of Vaccines·2021· 45 citedOpen Access
313 Stealthier mutanomes are induced after nivolumab immunotherapy
Regular and Young Investigator Award Abstracts·2021· 2 citedOpen Access
Highly conserved, non-human-like, and cross-reactive SARS-CoV-2 T cell epitopes for COVID-19 vaccine design and validation
npj Vaccines·2021· 42 citedOpen Access
Multi-step screening of neoantigens’ HLA- and TCR-interfaces improves prediction of survival
Scientific Reports·2021· 6 citedOpen Access
58 Excluding treg epitopes and integrating CD8 and CD4 effector neoepitope content improves prognostic biomarker tool in bladder cancer
Regular and Young Investigator Award Abstracts·2020Open Access
<i>Listeria monocytogenes</i> personalized cancer vaccines drive therapeutic immune responses to cancer derived neoantigens
2020· 1 citedOpen Access
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Frequent Co-authors

Robert G. Petit(10), Jack R. Bennink(9), Jonathan W. Yewdell(9), Daniel O. Villarreal(9), Cristina Mottershead(9), Elena V. Filippova(9), Brandon Coder(9), Andrew L'Huillier(8), Susan Armington(8), Benjamin Wolf(6), James S. Gibbs(5), Christopher C. Norbury(5), Anne S. De Groot(5), David Balli(5), Renée M. Laird(4), Guilhem Richard(4), Geraldine L. C. Paulus(4), Preethi Sankaran(4), Tanzila Rahman(4), Delainey O’Connor(4)