Delainey O’Connor

Fulcrum Therapeutics (United States) — United States

Immunology and Microbiology · Life Sciences

1h-index2citations5works0.42yr avg
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Research Topics

Immunotherapy and Immune Responses(2), CAR-T cell therapy research(2), Protease and Inhibitor Mechanisms(1), Cell Adhesion Molecules Research(1), Monoclonal and Polyclonal Antibodies Research(1)

Publications5 total

CBX–663, a novel TCR-mimetic T-cell engager targeting a telomerase reverse transcriptase (TERT) peptide-HLA complex, that exhibits potent efficacy against AML cells
Blood·2025
1299 Tri-specific T cell engager (TCE) targeting cathepsin G peptide-HLA (pHLA) complex with enhanced antileukemic activity via proprietary CD28 co-stimulation
Regular and Young Investigator Award Abstracts·2025Open Access
Abstract 3507: Discovery and preclinical characterization of novel TCR-mimetic T-cell engagers targeting TERT peptide-HLA complex for the treatment of solid and hematologic malignancies
Cancer Research·2025
CBX250 Is a Novel Cathepsin G Peptide-HLA-Targeting T Cell Engager That Exhibits High Tumor Antigen Selectivity and Potent Antileukemic Activity In Vivo
Blood·2024· 1 citedOpen Access
Abstract 1236: Characterization of CBX-250, a first-in-class TCR-mimetic-based T-cell engager targeting a cathepsin G peptide-HLA complex for the treatment of myeloid leukemia
Cancer Research·2024· 1 cited

Frequent Co-authors

Geraldine L. C. Paulus(5), Preethi Sankaran(5), Tanzila Rahman(5), Melissa J. Bikowitz(5), Sarah Jaffe(5), Bhupal Ban(5), Dmitri Wiederschain(5), Jennifer D. Helble(4), Alona Kulesha(4), Michael F. Princiotta(4), Benjamin Lee(4), Yü Huang(4), Chunhua Shi(3), Ningping Feng(3), Jeffrey J. Molldrem(3), Timothy P. Heffernan(3), Gheath Alatrash(3), Jessica Jimenez(3), Shawn O’Malley(3), Galina Gabriely(3)