Ladislav Vyklický

Czech Academy of Sciences — Czech Republic

Neuroscience · Life Sciences

56h-index9.8kcitations266works4.42yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(122), Ion channel regulation and function(98), Pain Mechanisms and Treatments(34), Receptor Mechanisms and Signaling(34), Neuroscience and Neural Engineering(27)

Publications257 total

Mice carrying a GluN2B protein-truncating variant have altered NMDA receptor subunit composition and their behavior recapitulates patient phenotypes
Cellular and Molecular Life Sciences·2026Open Access
Positive modulators of <i>N</i> -methyl- <scp>d</scp> -aspartate receptor: structure–activity relationship study on steroidal C-17 and C-20 oxime ethers
RSC Advances·2026Open Access
Positive Modulators of <i>N</i> -Methyl- <i>D</i> -Aspartate Receptor: Structure-Activity Relationship Study on Steroidal C-17 and C-20 Oxime Ethers
2025Open Access
Phenotype of mice carrying an NMDA receptor GluN2B protein-truncating variant associated with intellectual disability
2025Open Access
Disruption of <i>grin2A</i> , an Epilepsy-Associated Gene, Produces Altered Spontaneous Swim Behavior in Zebrafish
Journal of Neuroscience·2025· 1 citedOpen Access
Disruption of <i>grin2A</i> , an epilepsy-associated gene, produces altered spontaneous swim behavior in zebrafish
2025Open Access
Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology
Physiological Research·2024· 25 citedOpen Access
Characterization of Mice Carrying a Neurodevelopmental Disease-Associated GluN2B(L825V) Variant
Journal of Neuroscience·2024· 12 citedOpen Access
Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids
Cellular and Molecular Life Sciences·2024· 3 citedOpen Access
Analysis of Surface Expression of NMDAR Subunits in Primary Hippocampal Neurons
Methods in molecular biology·2024· 3 cited
Effects of Pregnanolone Glutamate and Its Metabolites on GABA<sub>A</sub> and NMDA Receptors and Zebrafish Behavior
ACS Chemical Neuroscience·2023· 10 citedOpen Access
Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine (DCK) in Wistar rats
Annales de Toxicologie Analytique·2022· 1 cited
Pregnane‐based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss‐of‐function disease‐associated <i>GRIN</i> mutations
British Journal of Pharmacology·2022· 13 citedOpen Access
Evidence for the Association between the Intronic Haplotypes of Ionotropic Glutamate Receptors and First-Episode Schizophrenia
Journal of Personalized Medicine·2021· 5 citedOpen Access
Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine in Wistar rats
British Journal of Pharmacology·2021· 11 citedOpen Access
Evidence for the association between the intronic haplotypes of ionotropic glutamate receptors and schizophrenia
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Evidence for the association between the intronic haplotypes of ionotropic glutamate receptors and schizophrenia
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia
Biomolecules·2021· 6 citedOpen Access
Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms
British Journal of Pharmacology·2021· 11 citedOpen Access
Palmitoylation Controls NMDA Receptor Function and Steroid Sensitivity
Journal of Neuroscience·2021· 22 citedOpen Access
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Frequent Co-authors

Viktorie Vlachová(12), Mark L. Mayer(9), Martin Hořák(9), Jan Krůšek(5), Jan Teisinger(5), Hana Chodounská(5), Vojtěch Vyklický(4), Miloslav Kořı́nek(4), Ivan Dittert(4), Klára Sušánková(4), Eva Syková(4), Jan Benedikt(4), A. Lundberg(4), N.‐E. Andén(3), M. G. M. Jukes(3), Tereza Smejkalová(3), Martina Kaniaková(3), Zdeňka Vitásková(3), Peter W. Reeh(3), Jiřina Borovská(3)