Joshua T. Mattila

University of Pittsburgh — United States

Medicine · Health Sciences

31h-index3.6kcitations81works13.12yr avg
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Research Topics

Tuberculosis Research and Epidemiology(62), Mycobacterium research and diagnosis(34), Infectious Diseases and Tuberculosis(12), Immune cells in cancer(10), interferon and immune responses(9)

Publications80 total

The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas
Nature Immunology·2026
Mycobacterium tuberculosis preferentially infects specific macrophage subsets in primate granulomas during the early stages of tuberculosis
Mucosal Immunology·2026
Development and hepatotoxicity of rifamycin derivatives
Expert Opinion on Drug Metabolism & Toxicology·2025
Spatially-distinct programming of macrophage diversity within the granulomas of <i>Mycobacterium tuberculosis</i> infected nonhuman primates
2025Open Access
Distinguishing multiple roles of T cell and macrophage involvement in determining lymph node fates during Mycobacterium tuberculosis infection
PLoS Computational Biology·2025· 3 citedOpen Access
The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control
2025· 11 citedOpen Access
How macrophage heterogeneity affects tuberculosis disease and therapy
Nature reviews. Immunology·2025· 49 cited
Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation
Cell Host & Microbe·2024· 35 citedOpen Access
The frequency of CD38+ alveolar macrophages correlates with early control of M. tuberculosis in the murine lung
Nature Communications·2024· 25 citedOpen Access
CD38+ Alveolar macrophages mediate early control of M. tuberculosis proliferation in the lung
2024· 2 citedOpen Access
Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
Mucosal Immunology·2024· 27 citedOpen Access
Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity
2024· 5 citedOpen Access
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
The Journal of Experimental Medicine·2023· 81 citedOpen Access
Cell painting assays for profiling responses in <i>Mycobacterium tuberculosis</i>-infected macrophages after metabolic perturbation
The Journal of Immunology·2023Open Access
Macrophages and neutrophils in lymph node granulomas from <i>Mycobacterium tuberculosis</i>-infected macaques have immunoregulatory phenotypes
The Journal of Immunology·2023Open Access
Type I IFN signaling mediates NET release to promote <i>Mycobacterium tuberculosis</i> replication and granuloma caseation
2022· 7 citedOpen Access
Macrophages and neutrophils express IFNλs in granulomas from Mycobacterium tuberculosis-infected nonhuman primates
Frontiers in Immunology·2022· 8 citedOpen Access
Inhibiting glycolysis by targeting the enzyme PFKFB3 restricts macrophage anti-mycobacterial activity and neutrophil phagocytosis of <i>Mycobacterium tuberculosis.</i>
The Journal of Immunology·2022
Bacteria load and hypoxia contribute to glucose uptake by macrophages and T cells in cynomolgus macaque granulomas
The Journal of Immunology·2022
Type III IFNs (IFNλs) expressed in tuberculosis (TB) granulomas enhance anti-mycobacterial activity of macrophages
The Journal of Immunology·2022
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Frequent Co-authors

JoAnne L. Flynn(27), Philana Ling Lin(19), Denise E. Kirschner(16), Pauline Maiello(11), Edwin Klein(9), Jennifer J. Linderman(9), Hannah P. Gideon(9), Stephanie Evans(6), Jia Yao Phuah(6), Alexander G. White(5), Jaime Tomko(5), Charles A. Scanga(5), James Butler(5), Ulrike G. Munderloh(5), Timothy J. Kurtti(5), Simeone Marino(4), Nicholas A. Cilfone(4), Nicole L. Grant(4), Sarah M. Fortune(4), Jess A. Millar(3)