Edwin Klein

University of Pittsburgh — United States

Medicine · Health Sciences

44h-index8.7kcitations123works6.52yr avg
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Research Topics

Tuberculosis Research and Epidemiology(46), Mycobacterium research and diagnosis(32), Infectious Diseases and Tuberculosis(24), Xenotransplantation and immune response(12), Immune responses and vaccinations(11)

Publications123 total

Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages
Mucosal Immunology·2025
Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques
2025Open Access
Protection against reinfection with <i>Mycobacterium tuberculosis</i> extends across heterologous Mtb lineages
2025Open Access
Characterizing PET CT patterns and bacterial dissemination features of tuberculosis relapse in the macaque model
Infection and Immunity·2025· 1 citedOpen Access
Characterizing PET CT patterns and bacterial dissemination features of tuberculosis relapse in the macaque model
2025Open Access
The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control
2025· 11 citedOpen Access
Term Infant With Apnea and Seizure-Like Activity
NeoReviews·2025
Intravenous BCG-mediated protection against tuberculosis requires CD4+ T cells and CD8α+ lymphocytes
The Journal of Experimental Medicine·2025· 26 citedOpen Access
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection
Immunity·2025· 2 citedOpen Access
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection
Immunity·2024· 35 citedOpen Access
CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques
2024· 8 citedOpen Access
Author Correction: Intravenous Bacille Calmette–Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis
Nature Microbiology·2024Open Access
Nanosphere pharmacodynamics improves safety of immunostimulatory cytokine therapy
iScience·2024· 2 citedOpen Access
CD4 <sup>+</sup> T cells are homeostatic regulators during <i>Mtb</i> reinfection
2023· 6 citedOpen Access
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
The Journal of Experimental Medicine·2023· 81 citedOpen Access
Intravenous Bacille Calmette–Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis
Nature Microbiology·2023· 33 citedOpen Access
Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques
Cell Host & Microbe·2023· 81 citedOpen Access
Vaccination with intravenous BCG protects macaques with pre-existing SIV infection from tuberculosis
2023· 6 citedOpen Access
Characterizing the Spectrum of Latent<i>Mycobacterium tuberculosis</i>in the Cynomolgus Macaque Model: Clinical, Immunologic, and Imaging Features of Evolution
The Journal of Infectious Diseases·2023· 9 citedOpen Access
T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques
Cell Reports·2022· 25 citedOpen Access
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Frequent Co-authors

JoAnne L. Flynn(28), Philana Ling Lin(22), Pauline Maiello(10), Jaime Tomko(9), Alexander G. White(8), Charles A. Scanga(8), Joshua T. Mattila(7), L. James Frye(7), David Ayares(7), Amy Myers(6), Hannah P. Gideon(6), Christopher Janssen(6), Hidetaka Hara(6), Mohamed Ezzelarab(6), David K. C. Cooper(6), Clifton E. Barry(5), Mark Rodgers(5), Saverio Capuano(5), Carl R. Fuhrman(5), Hayato Iwase(5)