Hayato Iwase

Johns Hopkins University — United States

Medicine · Health Sciences

35h-index3.5kcitations98works10.42yr avg
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Research Topics

Xenotransplantation and immune response(86), Animal Genetics and Reproduction(34), Organ Transplantation Techniques and Outcomes(25), Virus-based gene therapy research(24), T-cell and B-cell Immunology(14)

Publications98 total

Investigational New Drug Enabling Nonclinical Study of Xenogeneic Life-Supporting Porcine Kidneys With 10 Gene Edits (10 GE) in a Nonhuman Primate Test System.
PubMed·2026
Hypothermic machine perfusion prevents hyperacute graft loss in pig-to-primate kidney xenotransplantation after 5-hours of cold Ischemia
Communications Medicine·2025· 1 citedOpen Access
Routine cold storage leads to hyperacute graft loss in pig-to-primate kidney xenotransplantation; hypothermic machine perfusion may be preferred preservation modality in xenotransplantation
2024· 3 citedOpen Access
327.4: Long-term survival in pig-to-NHP kidney xenotransplantation with clinically relevant calcineurin inhibitor-based immunosuppression.
Transplantation·2024· 1 cited
447.9: Porcine islet-after-kidney transplantation in with cure of diabetes and six months of stable graft function in life-supporting pig-to-baboon model.
Transplantation·2024
447.2: Consistent long-term survival in consecutive cases of life-supporting porcine kidney xenotransplantation using 10GE source pigs.
Transplantation·2024
Consistent survival in consecutive cases of life-supporting porcine kidney xenotransplantation using 10GE source pigs
Nature Communications·2024· 62 citedOpen Access
Pretransplant Screening for Prevention of Hyperacute Graft Loss in Pig-to-primate Kidney Xenotransplantation
Transplantation·2024· 24 citedOpen Access
Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation
Frontiers in Immunology·2024· 3 citedOpen Access
412.4: Routine cold storage (5 hours) leads to hyperacute graft loss in pig-to-primate kidney xenotransplantation; hypothermic machine perfusion may be preferred preservation modality
Transplantation·2023· 1 cited
Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation
Annals of Transplantation·2022· 12 citedOpen Access
T and B lymphocyte dynamics after genetically-modified pig-to-baboon kidney xenotransplantation with an anti-CD40mAb-based immunosuppressive regimen
Transplant Immunology·2022· 9 citedOpen Access
The Role of Interleukin-6 (IL-6) in the Systemic Inflammatory Response in Xenograft Recipients and in Pig Kidney Xenograft Failure
Frontiers in Immunology·2021· 13 citedOpen Access
Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons
Xenotransplantation·2021· 19 citedOpen Access
Initial experimental experience of triple‐knockout pig red blood cells as potential sources for transfusion in alloimmunized patients with sickle cell disease
Transfusion·2021· 19 citedOpen Access
Lack of Effect of Human Chorionic Gonadotropin in Mixed Lymphocyte Reaction in Xenotransplantation
OBM Transplantation·2021Open Access
Stable expression of the human thrombomodulin transgene in pig endothelial cells is associated with a reduction in the inflammatory response
Cytokine·2021· 11 citedOpen Access
The Genetically Engineered Heart as a Bridge to Allotransplantation in Infants Just Around the Corner?
The Annals of Thoracic Surgery·2021· 49 cited
Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation
Xenotransplantation·2021· 15 cited
Evidence suggesting that deletion of expression of N‐glycolylneuraminic acid (Neu5Gc) in the organ‐source pig is associated with increased antibody‐mediated rejection of kidney transplants in baboons
Xenotransplantation·2021· 29 cited
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Frequent Co-authors

David K. C. Cooper(38), Hidetaka Hara(33), David Ayares(28), Mohamed Ezzelarab(26), Takayuki Yamamoto(15), Cassandra Long(12), Burcin Ekser(11), Abhijit Jagdale(10), Martin Wijkstrom(9), Devin E. Eckhoff(9), Jeremy B. Foote(8), Douglas J. Anderson(8), David K.C. Cooper(7), Mohamed H. Bikhet(7), Yi Wang(6), Edwin Klein(5), Zhongqiang Zhang(4), Carol J. Phelps(4), Whayoung Lee(4), Huy Nguyen(4)