Carol J. Phelps

Virginia Tech — United States

Medicine · Health Sciences

28h-index5.1kcitations93works0.02yr avg
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Research Topics

Xenotransplantation and immune response(41), Growth Hormone and Insulin-like Growth Factors(32), Animal Genetics and Reproduction(23), Organ Transplantation Techniques and Outcomes(14), Transplantation: Methods and Outcomes(11)

Publications93 total

Expression of human thrombomodulin by GalTKO.hCD46 pigs modulates coagulation cascade activation by endothelial cells and during ex vivo lung perfusion with human blood
Xenotransplantation·2023· 9 citedOpen Access
Increased human complement pathway regulatory protein gene dose is associated with increased endothelial expression and prolonged survival during ex‐vivo perfusion of GTKO pig lungs with human blood
Xenotransplantation·2023· 6 citedOpen Access
Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood
Xenotransplantation·2022· 14 citedOpen Access
hEPCR.hTBM.hCD47.hHO‐1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood
Xenotransplantation·2022· 6 citedOpen Access
Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models
Xenotransplantation·2021· 30 citedOpen Access
Pig-to-baboon lung xenotransplantation: Extended survival with targeted genetic modifications and pharmacologic treatments
American Journal of Transplantation·2021· 43 citedOpen Access
Stable expression of the human thrombomodulin transgene in pig endothelial cells is associated with a reduction in the inflammatory response
Cytokine·2021· 11 citedOpen Access
BETA4GALKO REDUCES ANTI-NON GAL ANTIBODY BINDING IN PIG-TO-BABOON AND PIG-TO-HUMAN LUNG TRANSPLANTATION MODELS
Transplantation·2020· 1 cited
HUMANIZED VON WILLEBRAND FACTOR REDUCES PLATELET SEQUESTRATION IN PIG XENOGENEIC LUNG PERFUSION AND PIG-TO-PRIMATE LUNG TRANSPLANTATION
Transplantation·2020· 1 cited
XENOGENEIC LUNG PERFUSION USING GALTKO.HCD46 LUNGS EXPRESSING HTFPI AND HCD47
Transplantation·2020
Gene-edited Pigs for Xenotransplantation
2020· 19 cited
Thromboxane and histamine mediate <scp>PVR</scp> elevation during xenogeneic pig lung perfusion with human blood
Xenotransplantation·2018· 15 citedOpen Access
Progress in Xenogeneic Lung Transplantation Using Multi-Transgenic Donor Pigs and Targeted Supportive Drug Treatments
Transplantation·2018· 4 cited
Genetic Engineering in Xenotransplantation
Transplantation·2018· 1 cited
P‐ and E‐selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage
Xenotransplantation·2018· 26 citedOpen Access
Synthetic liver function is detectable in transgenic porcine livers perfused with human blood
Xenotransplantation·2017· 15 citedOpen Access
Transgenic expression of human leukocyte antigen‐E attenuates Gal<scp>KO</scp>.h<scp>CD</scp>46 porcine lung xenograft injury
Xenotransplantation·2017· 51 cited
Immunological and physiological observations in baboons with life‐supporting genetically engineered pig kidney grafts
Xenotransplantation·2017· 213 cited
Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor
Xenotransplantation·2016· 27 cited
Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
Nature Communications·2016· 462 citedOpen Access
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Frequent Co-authors

David Ayares(28), David K. C. Cooper(12), Hidetaka Hara(12), Agnes M. Azimzadeh(10), Richard N. Pierson(9), Mohamed Ezzelarab(8), Lars Burdorf(8), Burcin Ekser(7), Cassandra Long(7), David L. Hurley(6), Todd Vaught(5), Suyapa Ball(5), Martin Wijkstrom(5), Christopher Laird(5), Arielle Cimeno(5), Dawn Parsell(5), Hayato Iwase(4), Amy Dandro(4), Beth M. French(4), Xiangfei Cheng(4)