Bruno M.D.C. Godinho

University of Massachusetts Chan Medical School — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index2.5kcitations49works13.42yr avg
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Research Topics

RNA Interference and Gene Delivery(37), Advanced biosensing and bioanalysis techniques(21), MicroRNA in disease regulation(14), RNA Research and Splicing(7), DNA and Nucleic Acid Chemistry(6)

Publications49 total

The 2025 Oligo Meeting in Budapest: Highlights of the 21st annual meeting of the oligonucleotide therapeutics society
Molecular Therapy — Nucleic Acids·2025Open Access
RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice
Molecular Therapy·2025· 4 citedOpen Access
Enhancing siRNA efficacy in vivo with extended nucleic acid backbones
Nature Biotechnology·2024· 37 cited
Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs
Molecular Therapy — Nucleic Acids·2024· 7 citedOpen Access
RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice
2024· 6 citedOpen Access
Silencing <i>Apoe</i> with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease
Alzheimer s & Dementia·2024· 30 citedOpen Access
A combinatorial approach for achieving CNS-selective RNAi
Nucleic Acids Research·2024· 10 citedOpen Access
Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice
Scientific Reports·2024· 13 citedOpen Access
RNA‐targeted therapy for Tau‐driven neuronal malfunction: preclinical screening
Alzheimer s & Dementia·2023Open Access
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo
2023· 4 citedOpen Access
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy <i>in vivo</i>
2023· 7 citedOpen Access
Desenvolvimento de novas metodologias para determinação de antibióticos em águas de consumo: estudo exploratório
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)·2023Open Access
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
Proceedings of the National Academy of Sciences·2023· 46 citedOpen Access
Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models
Nature Communications·2022· 46 citedOpen Access
A era dos medicamentos de ARN interferência: o panorama clínico dos fármacos para silenciamento génico
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)·2022· 6 citedOpen Access
Chemical engineering of therapeutic siRNAs for allele-specific gene silencing <i>in vivo</i> in CNS
2022Open Access
Silencing of <i>ApoE</i> with Divalent siRNAs Drives Activation of Immune Clearance Pathways and Improves Amyloid Pathology in Mouse Models of Alzheimer’s Disease
2022· 3 citedOpen Access
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs
Molecular Therapy — Nucleic Acids·2022· 23 citedOpen Access
Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System
Methods in molecular biology·2022· 1 citedOpen Access
Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep
JCI Insight·2021· 28 citedOpen Access
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Frequent Co-authors

Anastasia Khvorova(29), Dimas Echeverria(26), Matthew Hassler(22), Andrew H. Coles(18), Julia F. Alterman(16), Neil Aronin(15), Reka A. Haraszti(14), Chantal Ferguson(11), Caitríona M. O’Driscoll(11), John F. Cryan(11), Ellen Sapp(10), Marian DiFiglia(10), Nicholas McHugh(10), Ken Yamada(9), Annabelle Biscans(8), James W. Gilbert(8), Rachael Miller(7), Loïc Roux(7), Mehran Nikan(7), Samuel Hildebrand(7)