Samuel Hildebrand

University of Massachusetts Chan Medical School — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index387citations21works11.52yr avg
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Research Topics

RNA Interference and Gene Delivery(14), Advanced biosensing and bioanalysis techniques(12), DNA and Nucleic Acid Chemistry(4), MicroRNA in disease regulation(3), Alzheimer's disease research and treatments(2)

Publications21 total

Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs
Nucleic Acids Research·2025Open Access
Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington’s disease pathogenesis in mice
2025· 3 citedOpen Access
Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy
Nucleic Acids Research·2025· 11 citedOpen Access
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model
2025Open Access
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model
2025· 5 citedOpen Access
Potent and durable gene modulation in heart and muscle with chemically defined siRNAs
2024· 3 citedOpen Access
Enhancing siRNA efficacy in vivo with extended nucleic acid backbones
Nature Biotechnology·2024· 37 cited
Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA
Molecular Therapy — Nucleic Acids·2024· 4 citedOpen Access
A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system
Nucleic Acids Research·2024· 22 citedOpen Access
Silencing <i>Apoe</i> with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease
Alzheimer s & Dementia·2024· 30 citedOpen Access
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Nature Communications·2023· 45 citedOpen Access
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo
2023· 4 citedOpen Access
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy <i>in vivo</i>
2023· 7 citedOpen Access
Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors
RNA·2023· 1 citedOpen Access
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
Proceedings of the National Academy of Sciences·2023· 46 citedOpen Access
Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors
2022Open Access
Silencing of <i>ApoE</i> with Divalent siRNAs Drives Activation of Immune Clearance Pathways and Improves Amyloid Pathology in Mouse Models of Alzheimer’s Disease
2022· 3 citedOpen Access
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs
Molecular Therapy — Nucleic Acids·2022· 23 citedOpen Access
An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis
Molecular Therapy·2021· 45 citedOpen Access
Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity
Nucleic Acids Research·2021· 20 citedOpen Access
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Frequent Co-authors

Anastasia Khvorova(17), Dimas Echeverria(15), Nicholas McHugh(12), Ken Yamada(11), Jillian Caiazzi(11), Julia F. Alterman(11), Qi Tang(10), Ashley Summers(10), Vignesh Hariharan(9), Chantal Ferguson(9), Jacquelyn Sousa(8), Matthew Hassler(8), Raymond Furgal(8), David Cooper(7), Bruno M.D.C. Godinho(7), Brianna Bramato(6), Ellen Sapp(6), Marian DiFiglia(6), Neil Aronin(6), Daniel O’Reilly(5)