David D. Holcomb

Center for Biologics Evaluation and Research — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index549citations21works0.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(8), SARS-CoV-2 and COVID-19 Research(5), RNA modifications and cancer(5), RNA Research and Splicing(4), Monoclonal and Polyclonal Antibodies Research(4)

Publications21 total

Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity
Protein & Cell·2025Open Access
PB1316 Impact of Synonymous Gene Recoding on ADAMTS13
Research and Practice in Thrombosis and Haemostasis·2023Open Access
Protocol to identify host-viral protein interactions between coagulation-related proteins and their genetic variants with SARS-CoV-2 proteins
STAR Protocols·2022Open Access
Synonymous <i>ADAMTS13</i> variants impact molecular characteristics and contribute to variability in active protein abundance
Blood Advances·2022· 3 citedOpen Access
Structural, functional, and immunogenicity implications of <i>F9</i> gene recoding
Blood Advances·2022· 13 citedOpen Access
New approaches to predict the effect of co-occurring variants on protein characteristics
The American Journal of Human Genetics·2021· 9 citedOpen Access
A conserved epitope III on hepatitis C virus E2 protein has alternate conformations facilitating cell binding or virus neutralization
Proceedings of the National Academy of Sciences·2021· 6 citedOpen Access
In Silico Evaluation of Cyclophilin Inhibitors as Potential Treatment for SARS-CoV-2
Open Forum Infectious Diseases·2021· 6 citedOpen Access
Gene variants of coagulation related proteins that interact with SARS-CoV-2
PLoS Computational Biology·2021· 22 citedOpen Access
Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design
Scientific Reports·2020· 67 citedOpen Access
Ribosome profiling of HEK293T cells overexpressing codon optimized coagulation factor IX
F1000Research·2020· 3 citedOpen Access
Potential impact on coagulopathy of gene variants of coagulation related proteins that interact with SARS-CoV-2
2020· 6 citedOpen Access
In silico features of ADAMTS13 contributing to plasmatic ADAMTS13 levels in neonates with congenital heart disease
Thrombosis Research·2020· 4 citedOpen Access
Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design
2020· 27 citedOpen Access
Ribosome profiling of HEK293T cells overexpressing codon optimized coagulation factor IX
F1000Research·2020· 6 citedOpen Access
TissueCoCoPUTs: Novel Human Tissue-Specific Codon and Codon-Pair Usage Tables Based on Differential Tissue Gene Expression
Journal of Molecular Biology·2020· 79 cited
A Single Synonymous Variant (c.354G&gt;A [p.P118P]) in ADAMTS13 Confers Enhanced Specific Activity
International Journal of Molecular Sciences·2019· 27 citedOpen Access
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
Scientific Reports·2019· 73 citedOpen Access
Splicing dysregulation contributes to the pathogenicity of several <i>F9</i> exonic point variants
Molecular Genetics & Genomic Medicine·2019· 16 citedOpen Access
The Kazusa codon usage database, CoCoPUTs, and the value of up-to-date codon usage statistics
Infection Genetics and Evolution·2019· 11 cited
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Frequent Co-authors

Chava Kimchi‐Sarfaty(20), Nobuko Hamasaki‐Katagiri(17), Jacob Kames(15), Anton A. Komar(15), Upendra Katneni(13), Aikaterini Alexaki(12), Haim Bar(10), Ryan Hunt(9), Michael DiCuccio(9), John C. Athey(6), Nancy Hernandez(6), Juan C. Ibla(5), Gaya Hettiarachchi(5), Brian Lin(5), Kyle Laurie(5), Darón I. Freedberg(4), Zuben E. Sauna(4), Ofer Kimchi(4), Katarzyna I. Jankowska(3), Luis V. Santana‐Quintero(2)