James N.C. Kew

GlaxoSmithKline (United Kingdom) — United Kingdom

Neuroscience · Life Sciences

43h-index6.2kcitations83works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(48), Receptor Mechanisms and Signaling(34), Ion channel regulation and function(14), Nicotinic Acetylcholine Receptors Study(13), Neurotransmitter Receptor Influence on Behavior(10)

Publications82 total

Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes
Neuropsychopharmacology·2016· 16 citedOpen Access
Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
BMC Neuroscience·2013· 16 citedOpen Access
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2012· 16 citedOpen Access
Effects of the selective 5-HT7 receptor antagonist SB-269970 in animal models of psychosis and cognition
Behavioural Brain Research·2011· 58 cited
Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus
European Journal of Pharmacology·2011· 32 cited
Fractionation of Spatial Memory in GRM2/3 (mGlu2/mGlu3) Double Knockout Mice Reveals a Role for Group II Metabotropic Glutamate Receptors at the Interface Between Arousal and Cognition
Neuropsychopharmacology·2011· 60 citedOpen Access
Transcription and pathway analysis of the superior temporal cortex and anterior prefrontal cortex in schizophrenia
Journal of Neuroscience Research·2011· 91 cited
Hippocampal mossy fiber long‐term depression in Grm2/3 double knockout mice
Synapse·2011· 42 cited
ADAMTSL3 as a candidate gene for schizophrenia: Gene sequencing and ultra-high density association analysis by imputation
Schizophrenia Research·2011· 48 citedOpen Access
Neurochemical Characterisation of Group II Metabotropic Receptor Knockout Mice
Oxford University Research Archive (ORA) (University of Oxford)·2011
The muscarinic M4 receptor is the functionally predominant subtype in rat and mouse striatum as demonstrated using [35S] GTPγS binding
European Journal of Pharmacology·2010· 12 cited
Adenoviral-mediated Cre expression effectively suppresses GlyT1 binding in the thalamic area of GlyT1 conditional knock-out mice
Journal of Neuroscience Methods·2010· 3 cited
Identification of novel α7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods
Bioorganic & Medicinal Chemistry Letters·2010· 9 citedOpen Access
Ion channels : from structure to function
2010· 84 cited
Investigation of the H+–<i>myo</i>-inositol transporter (HMIT) as a neuronal regulator of phosphoinositide signalling
Biochemical Society Transactions·2009· 15 cited
Ion ChannelsFrom Structure to Function
Oxford University Press eBooks·2009· 14 cited
In vitro and in vivo characterization of PheTQS, a novel α7 nAChR positive allosteric modulator
Biochemical Pharmacology·2009· 1 cited
Medicinal Chemistry: Abstracts 56-105
CHIMIA International Journal for Chemistry·2009Open Access
Glutamate–Dopamine Crosstalk in the Rat Prefrontal Cortex is Modulated by Alpha7 Nicotinic Receptors and Potentiated by PNU-120596
Journal of Molecular Neuroscience·2009· 47 cited
Evaluation of expression and function of the H+/myo-inositol transporter HMIT
BMC Cell Biology·2009· 50 citedOpen Access
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Frequent Co-authors

John A. Kemp(17), Vincent Mutel(12), Pari Malherbe(7), Gerhard Trube(5), Ceri H. Davies(5), Peter R. Maycox(5), Guy A. Higgins(4), Paul J. Harrison(4), Philip W. J. Burnet(4), Susan Wonnacott(4), Jim J. Hagan(4), Lee A. Dawson(4), F. M. Kelly(4), M. H. Selina Mok(4), Frédéric Knoflach(3), J. G. Richards(3), John Richards(3), Abdel‐Mouttalib Ouagazzal(3), Horst Bluethmann(3), James A. Dickinson(3)