Pedro A. Lazo

Instituto de Investigación Biomédica de Salamanca — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

53h-index16.6kcitations220works2.02yr avg
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Research Topics

Nuclear Structure and Function(62), Cancer-related Molecular Pathways(38), Virus-based gene therapy research(34), Microtubule and mitosis dynamics(23), RNA Research and Splicing(23)

Publications215 total

VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes
Scientific Reports·2019· 38 citedOpen Access
Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase
Journal of Experimental & Clinical Cancer Research·2019· 63 citedOpen Access
VRK1 is required for the DNA damage response induced by temozolomide and by intercalating agents blocking transcription
2018
VRK1-mediated phosphorylation promotes Tip60/KAT5 accumulation and activity in response to DNA damage
2018
VRK1 depletion is associated to a defective DNA damage response after combining ionizing radiation and PARP inhibitors
2018Open Access
Characterization of VRK1 mutants implicated in human neurodegenerative diseases
2018Open Access
2018 CIC Samples KCNQ2 exon 7 partial duplication fastq files
DIGITAL.CSIC (Spanish National Research Council (CSIC))·2018Open Access
Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?
Cellular and Molecular Life Sciences·2018· 74 citedOpen Access
VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis
Cellular and Molecular Life Sciences·2018· 76 citedOpen Access
VRK2
2017
VRK3
2017
VRK1
2017
CD53
2017
Table of Contents
American Journal Of Pathology·2017Open Access
Reverting p53 activation after recovery of cellular stress to resume with cell cycle progression
Cellular Signalling·2017· 47 citedOpen Access
Is Centrosomal Protein 70, a Centrosomal Protein with New Roles in Breast Cancer Dissemination and Metastasis, a Facilitator of Epithelial-Mesenchymal Transition?
American Journal Of Pathology·2017· 4 citedOpen Access
VRK1
2017· 4 cited
Specific inhibition of chromatin remodelers and its connection with defects in DNA repair after inducing DNA damage
2017
Vaccinia related kinase 1 (VRK1) regulates the stability of Ataxin 1 (Atxn1)
DIGITAL.CSIC (Spanish National Research Council (CSIC))·2017
Specific inhibition of chromatin modifiers impairs the recruitment of DNA repair proteins at DNA damage sites
2017
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Frequent Co-authors

Sandra Blanco(12), Marta Sanz-García(11), Francisco M. De La Vega(10), Alberto Valbuena(8), Ana Sevilla(6), Ignacio Campillo‐Marcos(6), Marta Vázquez-Cedeira(5), Cláudio R. Santos(5), Inmaculada López-Sánchez(4), Marcella Salzano(4), Diana M. Monsalve(4), Isabel F. Fernández(4), Mónica Yunta(3), Ramiro Barcia(3), Montse Sánchez‐Céspedes(3), Susana López-Borges(2), Laia Simó‐Riudalbas(2), Cátia Moutinho(2), Sebastián Morán(2), Alberto Villanueva(2)