Hiroyuki Mizuguchi

National Institute of Biomedical Innovation, Health and Nutrition — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

67h-index17.8kcitations678works3.92yr avg
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Research Topics

Virus-based gene therapy research(289), RNA Interference and Gene Delivery(131), Viral Infectious Diseases and Gene Expression in Insects(105), CAR-T cell therapy research(71), CRISPR and Genetic Engineering(66)

Publications677 total

Extending a liver-based model to lung and intestine: a comparative study of CYP1A1 and CYP1A2 induction by cigarette smoke in human in vitro models
Archives of Toxicology·2026
Automated High-Throughput Raman Spectral Framework for Cellular Differentiation Monitoring
Nano Letters·2026
Oncolytic Reovirus-Induced Prostaglandin E2 Production in Human Tumor Cells
Biological and Pharmaceutical Bulletin·2025Open Access
Smoothened Agonist Treatment Mitigates Vasogenic Edema, Neuroinflammation, and Neurological Dysfunction Following Traumatic Brain Injury in Mice
The FASEB Journal·2025Open Access
Cryopreservation of Hepatocyte Organoid-Derived Cells Generated from Human iPS Cells
Biological and Pharmaceutical Bulletin·2025Open Access
[Results of a Special Drug Use-Results Survey on Palonosetron Hydrochloride in Patients Aged 18 Years and Younger].
PubMed·2025
Oncolytic adenovirus serotype 35 mediated tumor growth suppression <i>via</i> efficient activation of antitumor immunity
Journal for ImmunoTherapy of Cancer·2025· 2 citedOpen Access
Considerations for developing CYP induction assays in hepatocytes: Insights from a multilaboratory study
European Journal of Cell Biology·2025· 1 citedOpen Access
An in vitro safety evaluation model for assessing the effects of a chemical drug on the human intestinal barrier integrity using genetically modified Caco-2 cells expressing drug-metabolizing enzymes
Toxicology Letters·2025· 1 cited
Improvement of liver function and its long-term maintenance by applying synthetic matrices, hydrox, to primary human hepatocyte-derived organoids and their possible application in hepatotoxicity research
Drug Metabolism and Pharmacokinetics·2025
Phenotyping assay using genetically manipulated human IPS cell-derived hepatocyte- like cells
Drug Metabolism and Pharmacokinetics·2025
Development of organoid-derived enterocytes from human iPS cells or biopsied tissue for pharmaceutical research
Drug Metabolism and Pharmacokinetics·2025
Application of Human Liver Organoids for Pharmaceutical Research
YAKUGAKU ZASSHI·2025Open Access
Air-liquid interface culture alters the characteristics and functions of monolayers generated from human iPS cell‑derived enterocyte‑like cell organoids
European Journal of Cell Biology·2025· 4 citedOpen Access
Two-dimensionally cultured functional hepatocytes generated from human induced pluripotent stem cell-derived hepatic organoids for pharmaceutical research
Biomaterials·2025· 3 citedOpen Access
Contributors
Elsevier eBooks·2025
Adenoviral vector construction II: Bacterial systems
Elsevier eBooks·2025· 1 cited
Corrigendum to “Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study” [Drug Metabol Pharmacokinet 53 (2024) 100532]
Drug Metabolism and Pharmacokinetics·2024Open Access
Generation and application of CES1-knockout Tet-Off-regulated CYP3A4 and UGT1A1-expressing Caco-2 cells
Toxicology Letters·2024· 2 citedOpen Access
Transplacental delivery of factor IX Fc-fusion protein ameliorates bleeding phenotype of newborn hemophilia B mice
Journal of Controlled Release·2024Open Access
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Frequent Co-authors

Takao Hayakawa(23), Fuminori Sakurai(16), Kazuo Takayama(9), Kenji Kawabata(9), Katsuhisa Tashiro(6), Masashi Tachibana(6), Tadanori Mayumi(6), Yasuhito Nagamoto(5), Miho Furue(5), Kazufumi Katayama(5), Akiko Ishii‐Watabe(4), Mitsuru Inamura(4), T. Hayakawa(4), Shinsaku Nakagawa(4), Eriko Uchida(3), Mark A. Kay(3), Naoki Utoguchi(3), Naoya Koizumi(3), Naoki Okada(3), Zhili Xu(2)