Rienk Offringa

German Cancer Research Center — Germany

Immunology and Microbiology · Life Sciences

78h-index22.4kcitations356works11.32yr avg
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Research Topics

Immunotherapy and Immune Responses(175), CAR-T cell therapy research(103), Cancer Immunotherapy and Biomarkers(73), Immune Cell Function and Interaction(71), T-cell and B-cell Immunology(68)

Publications356 total

Genotype-phenotype mapping identifies fetal-like CD55 <sup>+</sup> immunoregulatory cancer cells as mediators of immune escape in colorectal cancer
2026Open Access
[Implementation of personalized T-cell therapy in the treatment of pancreatic cancer].
PubMed·2025
Enhanced mutanome analysis towards the induction of neoepitope-reactive T-cell responses for personalized immunotherapy of pancreatic cancer
Journal for ImmunoTherapy of Cancer·2025Open Access
Characterization of single neurons reprogrammed by pancreatic cancer
Nature·2025· 72 citedOpen Access
737 Optimal enhancement of anti-tumor T-cell immunity through the combined use of selective DGK zeta and DGK alpha inhibitors
Regular and Young Investigator Award Abstracts·2024· 3 citedOpen Access
729 Boosting anti-tumor immunity via triple combination of DGK, CCR8 and PD-L1 targeting agents
Regular and Young Investigator Award Abstracts·2024Open Access
Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T-Cell Immunity against Cancer
Journal of Medicinal Chemistry·2024· 13 citedOpen Access
Abstract B042: Dissection of the T cell infiltrate in mouse pancreatic tumors reveals a diverse tumor-reactive T cell repertoire targeting neoantigens and tumor-associated antigens
Cancer Research·2024
Abstract IA-02: The tumor-reactive CD8+ T-cell repertoire in pancreatic cancer as revealed by single-cell sequencing
Cancer Research·2024
optiPRM: A Targeted Immunopeptidomics LC-MS Workflow With Ultra-High Sensitivity for the Detection of Mutation-Derived Tumor Neoepitopes From Limited Input Material
Molecular & Cellular Proteomics·2024· 7 citedOpen Access
The enchanting canvas of CAR technology: Unveiling its wonders in non-neoplastic diseases
Med·2024· 9 citedOpen Access
Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy
Nature Biotechnology·2024· 51 citedOpen Access
Abstract B079: Identification of synergistic drug combinations including MEK inhibitor and agents modulating the tumor microenvironment in an electroporation-induced pancreatic cancer model
Cancer Research·2024· 1 cited
T-Cell-Based Platform for Functional Screening of T-Cell Receptors Identified in Single-Cell RNA Sequencing Data Sets of Tumor-Infiltrating T Cells
BIO-PROTOCOL·2024· 2 citedOpen Access
Identification of TRDV-TRAJ V domains in human and mouse T-cell receptor repertoires
Frontiers in Immunology·2023· 5 citedOpen Access
Transcriptome-based identification of tumor-reactive and bystander CD8 <sup>+</sup> T cell receptor clonotypes in human pancreatic cancer
Science Translational Medicine·2023· 35 cited
Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy
Journal for ImmunoTherapy of Cancer·2023· 65 citedOpen Access
926 BAY 2965501: a highly selective DGK zeta inhibitor for cancer immunotherapy
Regular and Young Investigator Award Abstracts·2023· 4 citedOpen Access
optiPRM: A targeted immunopeptidomics LC-MS workflow with ultra-high sensitivity for the detection of mutation-derived tumor neoepitopes from limited input material
2023Open Access
ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation
Cell chemical biology·2023· 35 cited
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Frequent Co-authors

Cornelis J.M. Melief(29), Sjoerd H. van der Burg(20), René E. M. Toes(15), Gemma G. Kenter(11), Jan W. Drijfhout(11), Gert Jan Fleuren(10), Kees L. M. C. Franken(8), Ellen I. H. van der Voort(7), Kitty M.C. Kwappenberg(7), Jan Paul Medema(7), W. Martin Kast(7), Cornelis J.M. Melief(6), Cornelis J.M. Melief(6), Ferry Ossendorp(6), Annemieke de Jong(6), Marij J.P. Welters(5), Jeanette M. van der Hulst(5), Delphine Réa(5), Roger P.M. Sutmuller(4), Joan de Jong(4)